Total Synthesis and Structure Confirmation of the Annonaceous

30(S)-Hydroxybullatacin, Uvarigrandin A, and 5(R)-Uvarigrandin A (Narumicin I?). James A. Marshall*, Arnaud Piettre, Mikell A. Paige, and Frederic...
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Vol. 68, 2003 James A. Marshall,* Arnaud Piettre, Mikell A. Paige, and Frederick Valeriote. Total Synthesis and Structure Confirmation of the Annonaceous Acetogenins 30(S)-Hydroxybullatacin, Uvarigrandin A, and 5(R)-Uvarigrandin A (Narumicin I?).

Page 1780. The concentration units for Table 1 were incorrectly listed as g/mL rather than µg/mL. The corrected table follows: TABLE 1. Cytotoxicity of Annonaceous Acetogenins toward H-116 Colon Cancer Cells compound (30S)-hydroxybullatacina uvarigrandin Aa (5R)-uvarigrandin Aa 5-fluorouracilb a

10-4

2× 2 × 10-4 2.5 × 10-4 1.5 × 10-1

1 µg/mL ≈ 1.5 µM. b 1 µg/mL ≈ 7 µM.

JO035268Y 10.1021/jo035268y Published on Web 09/18/2003

8290

IC50 (µg/mL)

J. Org. Chem. 2003, 68, 8290

IC90 (µg/mL) 2 × 10-1 1.5 × 10-2 3 × 10-1 1.5