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Understanding the origin of the regioselectivity in cyclopolymerizations of diynes shows how to completely switch it Hoimin Jung, Kijung Jung, Mannkyu Hong, Seongyeon Kwon, Kunsoon Kim, Soon Hyeok Hong, Tae-Lim Choi, and Mu-Hyun Baik J. Am. Chem. Soc., Just Accepted Manuscript • DOI: 10.1021/jacs.7b11968 • Publication Date (Web): 26 Dec 2017 Downloaded from http://pubs.acs.org on December 26, 2017
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Journal of the American Chemical Society
Understanding the origin of the regioselectivity in cyclopolymerizations of diynes shows how to completely switch it Hoimin Jung,a,b,‡ Kijung Jung,c,‡ Mannkyu Hong,a,b Seongyeon Kwon,a,b Kunsoon Kim,c Soon Hyeok Hong,c Tae-Lim Choi,c,* and Mu-Hyun Baikb,a,* a
Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic
of Korea b
Center for Catalytic Hydrocarbon Functionalizations, Institute for Basic Science (IBS), Daejeon, 34141, Republic of
Korea c
Department of Chemistry, Seoul National University, Seoul, 08826, Republic of Korea
ABSTRACT: Grubbs-type olefin metathesis catalysts are known to cyclopolymerize 1,6-heptadiynes to afford conjugated polyenes containing five- or six-membered carbocycles. Although high levels of regioselectivity up to >99:1 was observed previously for the formation of five-membered rings, it was neither possible to deliberately obtain six-membered rings at similar levels of selectivity, nor was it understood why certain catalysts showed this selectively. Combining experimental and computational methods, a novel and general theory for what controls the regiochemistry of these cyclopolymerizations is presented. The electronic demands of the ruthenium based Fischer carbenes are found to innately prefer to form fivemembered rings. Reducing the electrophilicity of the carbene by enforcing a trigonal-bipyramidal structure for the ruthenium, where stronger π-backdonation increases the electron density on the carbene, is predicted to invert the regioselectivity. Subsequent experiments provide strong support for the new concept and it is possible to completely switch the regioselectivity to a ratio of 99
69
8.9
1.12
>99:1
2
Ru1
M2
>99
73
15.2
1.34
>99:1
3
Ru1
M3
>99
98
10.1
1.26
>99:1
4
Ru1
M4
>99
97
12.6
1.11
>99:1
Ru1
M5
>99
82
12.7
1.12
>99:1
Ru2
M1
88
43
15.6
1.54
1:6.5
7
Ru2
M2
58
50
7.0
1.53
1:1.5
8
Ru2
M3
>99
75
10.4
1.97
≈1:1
9
Ru2
M4
96
79
13.1
1.65
1:1.7
10
Ru2
M5
62
49
6.3
1.41
1:1.4
6
f,g
5:6
e
entry
5
a
a
Reaction conditions: for the reaction using Ru1, 0.5 M in THF, 30 min.; for the reaction using Ru2, 0.25 M in THF, b
1
c
d
e
3 h. Determined from H NMR. Precipitated in MeOH at –78 °C. Determined from THF-SEC. 5-Membered:613
f
g
membered rings, determined from C NMR. Precipitated in hexane at –78 °C. M/I=50. Ru1 and Ru2 catalyzed cyclopolymerizations. Figure 2a and 2b show the calculated reaction energy profiles of the insertion step mediated by Ru1 and Ru2 catalysts. In the Ru1 system, the cyclopolymerization begins with the catalyst 1-0 that subsequently forms 1A-1, a π-complex with the heptadiyne substrate at 10.4 kcal/mol. The transition state 1A-1-TS to afford the α-addition product is found at a relative free energy of 19.0 kcal/mol, which is 9.2 kcal/mol lower in energy than for the transition state 1B-1-TS that leads to the β-addition product. This dramatic kinetic preference predicted for the α-addition at the insertion step is in excellent agreement with experimental results, where no β-addition product could be detected. Interestingly, the ruthenacyclobutene intermediate is not a proper minimum on the potential energy surface, as it ring-opens spontaneously to give the carbene intermediates 1A-3 and 1B-3 at –15.7 and –8.1 kcal/mol, respectively.
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Journal of the American Chemical Society
Figure 1. Generalized illustrations of the catalytic mechanism of the Ru-catalyzed alkyne cyclopolymerization.
When Ru2 is used, the reactant π-complex could not be obtained in our computer simulations, as the [2+2] cycloaddition was extremely facile and our attempts to locate the π-complex routinely gave the ruthenacyclobutene intermediate instead. We were able to locate the two transition states 2A-1-TS and 2B-1-TS at very low barriers of only 7.6 and 3.9 kcal/mol, respectively. This relatively low barrier of 3.9 kcal/mol is fully consistent with the experimental observation that the cyclopolymerization can be conducted at temperatures as low as –40 °C and this 10
is the temperature at which we conducted the cyclopolymerization to maximize the β-selectivity. The estimated barrier difference of 4 kcal/mol between the α- and β-additions appears overestimated as the observed selectivity is not high. But since the computations qualitatively agree with the experimental observations, we sought to understand the origin of the predicted selectivity in greater detail. The ruthenacyclobutene intermediates 2A-2 and 2B-2, which we were not able to optimize in the Ru1 system were located with the Ru2 system. They were almost isoenergetic with a –12.2 and –12.5 kcal/mol barrier, respectively. These ring intermediates can be isomerized to 2A-6 and 2B-6 by interchanging the position of the chelating nitrato ligand and the ruthenacycle moiety. The following ring opening transition states 2A-6-TS and 2b-6-TS lead to exergonic adducts 2A-7 and 2B-7 at –26.6 and –28.7 kcal/mol, respectively. The computer simulations are in excellent agreement with the experimental results that explain the observed selectivity. For both Ru1 and Ru2, the first insertion step is selectivity determining, because the overall cyclopolymerization process is considered to be irreversible.
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Figure 2. Insertion step free energy diagram of the (a) Ru1 system and the (b) Ru2 system. (black: α-addition, blue: β-addition, plain: favored, dashed: disfavored)
The origin of the selectivity. In conclusion, the strategy for inverting the regioselectivity by forcing the alkyne to bind in a side-on fashion is plausible but problematic, because the high reactivity associated with this pathway diminishes the selectivity. After some explorations, we concluded that attempts toward optimizing the Ru2-type catalyst to increase the β-selectivity, for example by functionalizing the NHC ligand, is not promising. Instead, a completely different strategy for regiocontrol based on the electronic demands of the Ru-carbene functionality emerged, as outlined in Figure 3. The Ru-catalysts are Fischer carbenes and the carbene fragment is best envisaged as a neutral ligand acting as a σ-donor and π-acceptor. Fischer carbenes have two major orbital interactions: (i) σ2
donation of sp -orbital of carbene carbon and (ii) π-backdonation from an empty p-orbital of the carbene center.
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Consequently, the carbene-carbon is an electrophile illustrated with a red “+”-sign in Figure 3a. Both electronic and steric effects can determine the regioselectivity of cyclopolymerization. Because the less substituted terminal position is more nucleophilic among the two alkyne-carbons of the substrate, the substrate-catalyst alignment leading to the α-addition is electronically preferred. The alignment leading to the β-addition, on the other hand, is electronically mismatched and disfavored. On the contrary, the steric demand of each catalyst shows clearly opposing properties as illustrated in Scheme 1b. In the octahedral Ru1 catalyst with bottom-bound demand, the steric hindrance between the metal carbene and the substituents in heptadiyne disfavors the β-addition. The Ru2 catalyst following side-bound mechanism prefers the β-addition sterically, as the substituents avoid the bulky mesityl group on the NHC ligand decorating the Ru catalyst as mentioned above. This opposing effect of the electronic and steric factors on cyclopolymerization enables us to understand which of the two properties dominates over each Ru1 and Ru2 catalyst. Previously, only steric controls were considered as the origin of the different selectivity in cyclopolymerization, however, we tried to link the electronic effect to switch the regiochemical outcome. The α-addition of Ru1 catalyst is clearly preferred by both steric and electronic demands, as it exclusively produces the sterically and electronically favored five-membered rings. Ru2 looks to follow the steric control only as the β-addition is sterically preferred with the side-bound system, however, we cannot exclude the electronic control since the catalyst structure of Ru2 is very different from Ru1 which is expected to lead to different carbene electronic properties. The structure of catalyst Ru2 is under equilibrium between octahedral and trigonal bipyramidal scaffolds due to the transient Ru–O bond. As explained in Figure 3c, the Ru-dxy orbital energy level of trigonal bipyramidal is higher than that of the octahedral geometry. On the other hand, the Ru-dx2-y2 orbital in trigonal bipyramidal structure is lower in energy compared to that found in the octahedral geometry. This energy level difference ultimately changes the electrophilicity of the metal carbene moiety, where the electrophilicity of the carbene-carbon may be reduced significantly by increased π-backdonation from the Ru-dxy into the empty carbene-p orbital. Consequently, we believe that the reduced electrophilicity demand of Ru2 compared to Ru1 as well as the intrinsic steric preference will be responsible for the inversed regiochemical outcome. We cannot fully establish that the electronic effect dominates the steric effect with Ru2, as the catalyst structure is not rigid, but we questioned if the electronic effect can be employed to control the regioselectivity. The electronic effect can be enhanced by enforcing a stringent trigonal bipyramidal geometry at the metal center, which raises the Ru-dxy energy, as illustrated in Figure 3c. Complete switch of the regioselectivity. These opposing trends in the electronic and steric demands may be an exploitable feature for engineering regioselective cyclopolymerizations. As mentioned above, we expect that the electronic bias towards α-addition is decreased in trigonal bipyramidal catalysts, as the electrophilicity of the carbene is reduced via π-backdonation. In general, octahedral catalysts should display the intrinsic preference for αaddition that is programmed into the Fischer carbene systems, as explained above. This intuitive structure-selectivity relationship was thus far not recognized and no attempts were made to exploit this feature for gaining regiocontrol
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over cyclopolymerizations. And accordingly, the regioselectivity was very sensitive to the catalyst structure as shown in Figure 3d.
Figure 3. (a) Electrophilic Fischer carbene model and its key metal-ligand interaction (b) Intrinsic electronic demand of a typical Ru-Fischer carbene with a 1,6-heptadiyne substrate (c) Qualitative molecular orbital diagram of carbene complexes (d) Complete switch of regioselectivity by using different Ru(II) catalysts posing different geometries.
The Ru1 catalyst displays an octahedral coordination geometry, where the carbene is arranged in the same plane as the two chloride ligands due to the orientation of the N-heterocyclic carbene ligand. Therefore, πbackdonation is less pronounced and the carbene in the Ru1 catalyst is electrophilic and the catalyst is α-selective, representing the typical reactivity profile of a classical Fischer carbene catalyst. The Ru2 catalyst, however, shows an equilibrium between an octahedral and trigonal bipyramidal structure and displays selectivity only at moderate levels.
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Journal of the American Chemical Society
We tested the Hoveyda’s Z-selective catalyst (Ru3),
21, 22
a new Ru-based catalyst for cyclopolymerization which has a
strict trigonal bipyramidal structure. Ru3 adopts a trigonal bipyramidal coordination geometry and should show βselective cyclopolymerizations according to our conceptual proposal on the electrophilicity, as long as the standard side-bottom reaction pathway
23
with respect to the NHC ligand is followed. This catalyst contains a bidentate
catecholthiolate ligand, where the two anionic ligands were forced to arrange in a syn orientation to each other to 24
give high reactivity and Z-selectivity in various cross metathesis reactions. Figure 4 shows the computed free energy diagram of the cyclopolymerization using Ru3. The catalysis starts by Ru3 engaging the diyne reactant to form 3-1 at 7.5 kcal/mol. Interestingly, the β-insertion is associated with a barrier of only 13.5 kcal/mol, which is 7 kcal/mol lower than what is found for the α-insertion. The reaction continues by the ruthenacyclobutene intermediate 3B-2 undergoing a structural rearrangement to afford intermediate 3B-6 that ring-opens to give 3B-7. This reaction energy profile suggests a complete reversal of the regioselectivity seen with Ru1, where both the computed barriers of 14–19 kcal/mol for the preferred pathway and the difference to the other regioisomer of ~7 kcal/mol are comparable. Thus, we anticipate a similar reactivity profile in terms of catalyst performance and degree of selectivity for Ru1 and Ru3, except for the fact that the selectivities are entirely reversed. If correct, Ru3 may allow for overcoming the performance problems such as narrow monomer scope and moderate β-selectivity at ambient temperature that were encountered previously with Ru2.
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Figure 4. Insertion step free energy diagram of the Ru3 system. (black: α-addition, blue: β-addition, plain: favored, dashed: disfavored) Table 2. β-Selective cyclopolymerization of various 1,6-heptadiynes using Ru3
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Journal of the American Chemical Society entry
1
yield b (%)
Mn c (kDa)
PDI
e
M1
95
93
16.1
1.71
1:16.1
2
M2
84
53
15.3
1.61
1:11.8
3
M3
51
47
6.7
1.51
99
89
19.6
1.79
99
70
25.8
1.92
