Editorial pubs.acs.org/ac
Analytical Methods in Toxicology
T
his is the premise of toxicology“The dose makes the poison”. As Paracelsus (1497−1541) stated, “Alle Ding sind Gif t, und nichts ohn Gif t; allein die Dosis macht, daß ein Ding kein Gif t ist.” or “All things are poison and nothing is without poison, only the dose permits something not to be poisonous.” All dose−response relations require the determination or assessment of the dose or concentration. Analytical chemistry plays an important role in chemical toxicology research. Various analytical techniques and assays enable the determination of the dose or concentration of the test chemical. Furthermore, the need to characterize metabolites, detect molecular interactions, and understand the toxic effects drives the development of new analytical technology. Recognizing the synergistic interplay between the development of analytical technology/assays and their applications to chemical toxicology research, we compiled this virtual issue on “Analytical Methods in Toxicology”. Papers in this virtual issue are selected from the most recent (2013 and 2014) publications in Analytical Chemistry and Chemical Research in Toxicology. Recent developments in analytical methods for toxicological research cover a diverse range. This virtual issue represents some of the advances in the development of analytical methods and their applications in chemical toxicology. Mass spectrometry and its hyphenation with chromatography and capillary electrophoresis, field-flow fractionation, microfluidics, cellbased biosensors and nanosensors, fluorescence, cavity ringdown spectroscopy, and voltammetric microwell array are highlighted in this collection. These techniques have been applied to the determination of toxic chemicals, their metabolites, and their interaction products with proteins and DNA. The results contribute to the development of biomarkers of exposure and to the assessment of the biological consequences of exposure. We hope that this collection will further stimulate interdisciplinary research in analytical chemistry and chemical toxicology.
X. Chris Le*
University of Alberta, Edmonton, Alberta, Canada
Yinsheng Wang*
■
University of California, Riverside, California, United States
AUTHOR INFORMATION
Corresponding Authors
*E-mail:
[email protected]. *E-mail:
[email protected]. Notes
Views expressed in this editorial are those of the author and not necessarily the views of the ACS.
Published: December 16, 2014 © 2014 American Chemical Society
11929
dx.doi.org/10.1021/ac5043472 | Anal. Chem. 2014, 86, 11929−11929
