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DATE THURSDAY JUNE 22, 2017
TIME 8:00 A.M. PDT / 11:00 A.M. EDT / 16:00 BST / 17:00 CEST
Lab of Today: Tips for Setting up Great Research Labs
SPEAKER
OVERVIEW
Craig Lindsley
When establishing a new laboratory for research into chemical biology and drug discovery, what are the criteria you should keep in mind?
e speakers
for this webinar will discuss how to assess the needs for equipment, space
Co-Director and Director of Medicinal Chemistry, Vanderbilt Center for Neuroscience Drug Discovery
and personnel to set up a thriving research environment. Craig Lindsley of Vanderbilt University will discuss the key instrumentation in medicinal
SPEAKER
chemistry, pharmacology and other related disciplines to enable drug discovery in an academic environment. Brendan Beahm of Aiken BioSciences will discuss on how to set up operations for a small startup biotechnology company and bring in his experience in establishing Carolyn Bertozzi’s laboratory in chemical biology a few years ago at Stanford University.
e
webinar will delve into the details of how to set up a laboratory poised to do
Brendan Beahm
notable research and development by ensuring that the proper investment is
Principal Scientist at Aiken Biosciences
made into equipment, facilities and people.
MODERATOR KEY LEARNING OBJECTIVES: Q
e essential instruments across disciplines of drug discovery and
WHO SHOULD ATTEND: Q
New principal investigators
Q
Laboratory managers
Q
Technicians
Q
Academic drug hunters
Q
Scientists at start-up
chemical biology Q
e integration of various research platforms
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Determination of space requirements for the laboratory’s
biotechnology companies
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Investment in personnel
REGISTER NOW visit http://bit.ly/laboftoday
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tivity,” Livingston says. “This means we can have a more accurate separation of molecules at a higher processing rate with lower consumption of energy.” Although membranes dominate the conversation, researchers are devising multiple options to tackle nonthermal separations. For example, Taiwan’s nonprofit Industrial Technology Research Institute (ITRI) has created “green glass adsorbent technology.” The technology, designed specifically for removing heavy-metal ions such as arsenic, cadmium, chromium, and lead from industrial and mining wastewater without distilling or evaporating water, was a finalist in the 2016 R&D 100 Awards given by R&D Magazine. Rather than bury tons of waste from liquid-crystal display panels in landfills, ITRI researchers identified a crushing and extraction process that separates the liquid crystals and the indium coating on the glass for recycling while creating a porous adsorbent material from the glass itself. When added to water, the adsorbent extracts heavy metals. Then the collected metal ions can be desorbed, concentrated, and recycled, and the glass adsorbent gets regenerated and reused. The green glass adsorbent is less costly and has a
wider range of applications than ion-exchange resins or chemical processes such as precipitation and coagulation that are currently used, according to ITRI deputy director Huan-I Hung. In another case of membraneless separation, Martin Z. Bazant of Massachusetts Institute of Technology and coworkers are working on a system that uses an electrically driven shock wave to purify a flowing stream of salty water. In this process, called shock electrodialysis, water flows through a porous glass frit. When an electric current is applied to the frit, the water divides into regions where the salt concentration is either depleted or enriched. When the current becomes strong enough, it generates a shock wave between these two zones, dividing the streams and allowing the fresh and salty water to be separated. “AltSep is directly aligned with our goals of making industrial separations more energy and capital efficient,” says Hannah Murnen, vice president of business development at AltSep industrial collaborator Compact Membrane Systems. In particular, the program is providing valuable networking for her company and other organizations interested in advancing separation technologies, Murnen adds.
Compact Membrane Systems has developed a fluoropolymer membrane system containing silver ions, called Optiperm, for gas-phase separation of light olefins and alkanes. As a gas stream under pressure passes down the center of a spiral-wound membrane cartridge, silver ions in the membrane interact with the olefins, forming complexes that shuttle the olefins through the membrane as the alkanes proceed onward. Metal-mediated separations aren’t new, but before now researchers haven’t been able to find a material and processing system that can both embed silver and perform over a long time without fouling. Optiperm was recognized for its benefit over conventional column distillation by being selected as the overall winner in the 2016 ICIS Innovation Awards presented by chemical information services firm ICIS. Murnen says a plant-scale propylene-propane Optiperm demonstration project is due to start up at Delaware City Refining Co. this summer. “Membranes are one of the best ways that we as a chemical community can make separations more efficient,” Murnen says. “And AltSep is focused on making the use of them a reality rather than an interesting laboratory project.” ◾
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Founded in 1999, PurThread buys its Environmental Protection Agency-registered silver ingredient from Eastman Kodak, the former photographic film giant, says Lisa Grimes, PurThread’s chief executive officer. A target market is soldiers who may have to wear clothing in the field for an extended period of time. Fashionistas may also benefit. The antimicrobial threads can maintain the new look of denim longer by avoiding frequent washing, Grimes says. Other U.S. firms are also introducing fiber and yarn additives that provide special attributes. Once the additives go into the polyester and nylon yarns that Unifi extrudes, “they’re in the fabric for life,” says Jay Hertwig, a vice president. Additives in Unifi’s yarns include phosphorus-based flame retardants. Polyester curtains containing the additive will still melt in a fire, but they won’t ignite and encourage flame spread. Other Unifi yarns contain additives that repel water and protect fabric from the degrading effects of ultraviolet light. In addition to using virgin polymers to produce its yarns, Unifi has developed a line of fibers, sold under the Repreve name, made from recycled polyester bottles. The company operates its own recycling center
®
American Chemical Society
that converts bottles into polyester chips. A chemical tracer added to the polyester allows customers to verify the recycled content. New technology is also coming to textile finishing. Like PurThread, APJeT developed its technology at NCSUCT. The firm’s atmospheric pressure plasma jet technology, based on know-how from Los Alamos National Laboratory, uses a blend of gases to apply water-repellent, fire-retardant, and soil- and stain-resistant fabric finishes. APJeT claims that its process completely eliminates the large amounts of water necessary to finish most textiles. It also says the process uses only 10% of the chemicals needed in traditional fabric finishing. Also infusing new life into textile fibers are traditional fiber makers. In January, Eastman Chemical launched a new acetate fiber, dubbed Naia, made with wood pulp “derived exclusively from sustainably managed and certified forests.” And last year, in partnership with Unifi, Eastman launched Avra fibers, made by extruding polyester into fibers too thin to be woven or knitted on their own. The fibers are held together by a polymer that is washed away after the fabric is made. Sports apparel made with Avra has a silky feel and is able to wick mois-
ture away from the skin, Eastman says. Beyond new fibers and yarns, some innovators are looking to embed textiles with sensors to create “smart fabric.” Keith McMillen, who heads BeBop Sensors in California, explains that his firm does this by chemically treating fabric with conductive polymer coatings. When a user stretches or puts pressure on the fabric sensors, current flow is affected, McMillen says. Printed electronic traces bring signals from the sensors to a computer chip that can measure a runner’s gait, monitor a wearer’s heart rate, or sense a person’s body temperature. BeBop recently introduced a control glove for virtual-reality enthusiasts. Equipped with haptic sensors, the glove allows users to “feel” objects virtually when playing computer games. Also on the drawing board are car seat sensors linked to airbag deployment systems to better protect occupants in case of a crash, McMillen says. “The name of the game for U.S. producers is product differentiation,” IHS Markit’s Merrill observes of the textile industry today. Specialized products could eventually make a dramatic difference for U.S. fiber and fabric output, Merrill says. But in his view, that isn’t likely to happen for another decade or more. ◾
EMPOWER SCIENTISTS OF THE FUTURE
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Something new is coming in peer review. Announcing ACS Reviewer LabTM, a free online course from ACS Publications, designed to educate researchers on the fundamentals of peer review featuring six modules and interactive assessments.
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