books and software
BIOANALYTICAL b HPLC Methods for Recently Approved Pharmaceuticals George Lunn John Wiley & Sons, 2005, 717 pp, $150, www.wiley.com This book, a continuation of four earlier volumes, contains procedures for analyzing 392 pharmaceuticals and covers the literature through 2003. The drugs are divided into three categories: those approved since the earlier volumes were published, those previously approved but for which no analytical method was published, and those for which procedures for measurement in blood have become available since the earlier volumes. Most of the entries list the following: matrix, sample preparation, guard column, column, mobile phase, flow rate, injection volume, retention time, detector, internal standard, column temperature, extracted (other compounds that can be extracted and analyzed at the same time but that do not interfere), simultaneous (other compounds that can be analyzed at the same time but that do not interfere), also (other compounds that can be analyzed at the same time), noninterfering, interfering, detection limit, quantitation limit, key words, and reference. A cumulative index contains a comprehensive listing of all the drugs (>2000) in all 5 volumes and in Capillary Electrophoresis Methods for Pharmaceutical Analysis. b Chemoinformatics: Concepts, Methods, and Tools for Drug Discovery Jürgen Bajorath, Ed. Humana Press, 2004, 524 pp, $125, http://humanapress.com Among the topics covered by the book’s 19 chapters are molecular similarity, informative compound sets, quantitative structure–activity relationships, molecular descriptors, cell-based partitioning, recursive partitioning analysis, combinatorial libraries, and annealing. Roughly one-third of the contributing authors are academics; the others work for pharmaceutical companies. U.S. authors predominate, but Switzerland, the U.K., France, and Canada are also represented. 358 A
b HPLC of Peptides and Proteins: Methods and Protocols Marie-Isabel Aguilar, Ed. Humana Press, 2004, 413 pp, $100, http://humanapress.com The book is divided into sections on modes of HPLC, preparative methodologies, and applications. Some of the topics covered in the first two sections include reversed-phase, micropreparative, multidimensional, and analytical HPLCs; ion-exchange, hydrophobic interaction, gel-filtration, metal-ion-affinity, large-scale protein, and immunoaffinity chromatographies; LC/MS; and capillary separations. The applications chapters cover proteolytic peptides, MS of posttranslationally modified proteins, glycopeptides and glycoproteins by LC/ MS, peptide metabolism, intrinsic membrane proteins, IgG purification, and analysis of Australian funnel-web spider venom. b Protein Arrays: Methods and Protocols Eric T. Fung, Ed. Humana Press, 2004, 287 pp, $100, http://humanapress.com According to the preface, this book is an introduction to protein array technology and multiplexed detection of proteins. Some of the 23 chapter titles are Protein Expression Arrays for Proteomics, Multiplexed Protein Analysis using Spotted Antibody Microarrays, Streptavidin–Biotin-Based Microarray Platform for Immunoassays, Processing Photoaptamer Microarrays, Printing Functional Protein Microarrays Using Piezoelectric Capillaries, Cytokine Protein Arrays, and Protein Arrays for Serodiagnosis of Disease. b Quantitation of Amino Acids and Amines by Chromatography: Methods and Protocols Ibolya Molnár-Perl, Ed. Elsevier, 2005, 655 pp, $270, www.elsevier.com According to the preface, this book, volume 70 in the Journal of Chromatography series, is intended to serve as a readyto-use guide to identifying and quantifying amino acids and amines. The book is
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divided into four parts: amino acids, amines, simultaneous quantitation of amino acids and amines, and quantitation of polyamines by chromatography. The sections on amino acids and amines cover GC, HPLC, and CE/capillary electrochromatography of their respective compounds, with a good deal of emphasis on derivatization.
SEPARATIONS b Chiral Pollutants: Distribution, Toxicity, and Analysis by Chromatography and Capillary Electrophoresis Imran Ali and Hassan Y. Aboul-Enein John Wiley & Sons, 2004, 344 pp, $175, www.wiley.com The chapters in this book cover the sources, distribution, biotransformation, biodegradation, metabolism, and toxicity of chiral pollutants. Also discussed are the measurement of chiral pollutants by GC, HPLC, micellar electrokinetic chromatography, supercritical fluid chromatography, TLC, and CE. Chapters on sample preparation and regulations and economics are also included. b Chromatography: Concepts and Contrasts James M. Miller John Wiley & Sons, 2005, 490 pp, $95, www.wiley.com According to the preface, this second edition has “the same rationale, organization, objectives, and academic level [third-year undergraduate] as the first edition.” It has been updated to include multidimensional chromatography, chiral separations, MS detection, and biological applications. Other topics have been expanded, and a new chapter on industrial and governmental regulatory practices has been added. Topics covered by the chapters also include band broadening and kinetics, optimization, GC, LC, detectors and quantitation, planar chromatography, CE, and sample preparation. The references number nearly 1000, of which many are websites. The book also has a glossary; typical calculations; and a list of symbols, acronyms, and abbreviations. © 2005 AMERICAN CHEMICAL SOCIETY
books and software
b Advances in Chromatography, Vol. 43 Phyllis R. Brown, Eli Grushka, and Susan Lunte, Eds. Marcel Dekker, 2005, 323 pp, $189.95, www.dekker.com The five sections in this book, written by nine contributing authors, cover retention and separation optimization in gradient elution; supercritical fluids for off-line sample preparation; the relationship between chromatography, singlemolecule dynamics, and equilibrium; solid-phase microextraction; and polyelectrolytes as stationary phases. b Chiral Separations: Methods and Protocols Gerald Gübitz and Martin G. Schmid, Ed. Humana Press, 2004, 432 pp, $100, http://humanapress.com Topics covered by the book’s 25 chapters include separation of enantiomers by TLC; cyclodextrin, glycopeptide, polysaccharide, and Pirkle chiral stationary phases; ligand exchange; molecularly imprinted polymers; benzofurazan reagents; CE separations using macrocyclic and glycopeptide antibiotics, proteins, cellulases, crown ethers, cinchona alkaloid derivatives, polysaccharides, nonaqueous media, and cyclodextrins; supercritical fluid and micellar electrokinetic chromatographies; and capillary electrochromatography.
INSTRUMENTATION
NMR; electron paramagnetic resonance; potentiometry; electrochemical stripping; electrolytic conductance; labs on chips; biosensors; HPLC; GC; supercritical fluid, countercurrent, and size-exclusion chromatographies; CE; field-flow fractionation; TLC; and inductively coupled plasma–optical emission spectrometry.
SPECTROSCOPY b Practical NMR Relaxation for Chemists Vladimir I. Bakhmutov John Wiley & Sons, 2004, 202 pp, $90, www.wiley.com The preface states that this book’s “task is simple: to show in practice how relaxation experiments on protons, deuterons, or other nuclei can be applied for qualitative structural diagnostics in solutions, quantitative structural determinations, recognition of weak intermolecular interactions, and studies of molecular mobility.” Complex quantum mechanical descriptions are avoided; instead, the author uses macroscopic equations that have been converted into simpler forms that are convenient for applications. The topics covered by the 12 chapters include how to measure relaxation times, errors, dipole–dipole and quadrupole interactions, molecular systems with anisotropic motions, deuterium quadrupole coupling, and paramagnetic NMR relaxation. Each chapter is generously illustrated.
b High-Resolution Continuum Source AAS: The Better Way to Do Atomic Absorption Spectrometry B. Welz, H. Becker-Ross, S. Florek, and U. Heitmann Wiley–VCH, 2005, 295 pp, $130, www.wiley.com The chapter titles are Historical Development of Continuum Source AAS, Theoretical Concepts, Instrumentation for HR-CS AAS, Special Features of HR-CS AAS, Measurement Principle in HR-CS AAS, Individual Elements (covering 48 elements), Electron Excitation Spectra of Diatomic Molecules, Specific Applications, and Outlook. A list of physical constants, symbols, and abbreviations as well as an index are included. Of the 161 references, most are from the 1980s onward.
ELECTROANALYTICAL b Electroanalytical Chemistry, Vol. 22 Allen J. Bard and Israel Rubinstein, Eds. Marcel Dekker, 2004, 310 pp, $199.95, www.dekker.com The eight contributing authors are from Tel Aviv University (Israel), Brookhaven National Laboratory, and Michigan State University. The three sections cover analyzing the metal–solution interface with the electrochemical quartz-crystal microbalance, the indirect laser-induced temperature-jump method for characterizing fast interfacial electron transfer, and electrically conducting diamond thin films.
b Ewing’s Analytical Instrumentation Handbook Jack Cazes, Ed. Marcel Dekker, 2005, 1037 pp, $249.95, www.dekker.com
b Molecular Light Scattering and Optical Activity Laurence Barron Cambridge University Press, 2004, 443 pp, $150, www.cambridge.org
b Electrochemical Detection in HPLC R. J. Flanagan, D. Perrett, and R. Whelpton Royal Society of Chemistry, 2005, 230 pp, $140, www.rsc.org
This third-edition tome is intended as a desk reference for those who need specific information about a particular instrumental technique or those looking for references on theory and methodology. Topics covered in the 31 chapters include computers; flow and sequential injection analysis; atomic absorption; spectrophotometers; fluorescence; X-ray methods; vibrational, photoacoustic, Auger, X-ray photoelectron, and chiroptical spectroscopies; MS; thermoanalysis; voltammetry;
According to the preface, this “is not a comprehensive treatise on optical activity and remains a personal view of the theory of optical activity and related polarized light scattering effects that reflects [Barron’s] research interests.” The eight chapters cover optical activity phenomena; molecules in electric and magnetic fields; molecular scattering of polarized light; symmetry; natural electronic, natural vibrational, and magnetic electronic optical activity; and antisymmetric scattering.
The seven chapters cover basic electrochemistry; electrochemical detectors; troubleshooting; thiols, disulfides, and related compounds; applications for 35 types of pharmaceuticals (each type lists several drugs); and toxicological applications. The pharmaceutical applications chapter has 400 of the book’s 650 references. The detectors chapter discusses construction; amperometric, coulometric, and pulsed detection modes; multiple detection systems; and microdetectors.
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