Monograph pubs.acs.org/doi/book/10.1021/acsreagents
Glycine (Aminoacetic Acid) Part 4, Monographs for Reagent Chemicals: General Descriptions, Specifications, and Tests eISBN: 9780841230460 Tom Tyner Chair, ACS Committee on Analytical Reagents James Francis Secretary, ACS Committee on Analytical Reagents
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A u t h o r i t a t i v e V e r s i o n : This version is current as of 01 Jun 2016.
ABSTRACT This monograph for Glycine provides, in addition to common physical constants, a general description including typical appearance, applications, change in state (approximate), and aqueous solubility. The monograph also details the following specifications and corresponding tests for verifying that a substance meets ACS Reagent Grade specifications including: Assay, Residue after Ignition, Heavy Metals, Chloride, Sulfate, Ammonium, Substances Darkened by Sulfuric Acid, and Hydrolyzable Substances.
O H2N
H2NCH2COOH
OH
Formula Wt 75.07
CAS No. 56-40-6
SUPPLEMENTS & UPDATES Published
Authoritative
28 Feb 2017
01 Jun 2016
Expired
Type
Summary
Original
First on-line publication, based on 11th ed.
Other Versions
GENERAL DESCRIPTION Typical appearance . . . . . . . . Applications . . . . . . . . . . . . . Change in state (approximate) . Aqueous solubility . . . . . . . . .
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© 2017 American Chemical Society
white solid buffer decomposes at 233 °C 25.0 g in 100 mL at 25 °C
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DOI:10.1021/acsreagents.4155.20160601 ACS Reagent Chemicals, Part 4
ACS Reagent Chemicals
Monograph
pubs.acs.org/doi/book/10.1021/acsreagents
SPECIFICATIONS Assay . . . . . . . . . . . . . . . . . . . . . . . . . . . . ≥98.5% H2NCH2COOH
Residue after ignition. . . . . . . . . . . Heavy metals (as Pb) . . . . . . . . . . . Chloride (Cl) . . . . . . . . . . . . . . . . Sulfate (SO4) . . . . . . . . . . . . . . . . Ammonium (NH4) . . . . . . . . . . . . . Substances darkened by sulfuric acid . Hydrolyzable substances . . . . . . . . .
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Maximum Allowable 0.1% 0.002% 0.005% 0.005% 0.005% Passes test Passes test
TESTS Assay (Total alkalinity by nonaqueous titration). Weigh accurately 0.25 g, and dissolve in 100 mL of glacial acetic acid. Add 0.5 mL of crystal violet indicator solution, and titrate with 0.1 N perchloric acid in glacial acetic acid volumetric solution to a green end point. Correct for a blank. One milliliter of 0.1 N perchloric acid corresponds to 0.007507 g of H2NCH2COOH. % H 2NCH 2COOH =
{[mL (sample)
mL (blank)] × N HClO4 } × 7.507 Sample wt (g)
Residue after Ignition [Part 2: Gravimetric Methods; Residue after Ignition]. Use 2.0 g.
Heavy Metals [Part 2: Colorimetry and Turbidimetry; Heavy Metals (as Lead); Procedure for Heavy Metals, Method 1]. Use 1.0 g.
Chloride [Part 2: Colorimetry and Turbidimetry; Chloride]. Use 0.2 g.
Sulfate [Part 2: Colorimetry and Turbidimetry; Sulfate; Procedure for Sulfate, Method 1]. Use 1.0 g.
Ammonium (By colorimetry, [Part 2: Colorimetry and Turbidimetry; Ammonium (Test for Ammonia and Amines)]). Use 0.2 g. For the standard, use 0.01 mg of ammonium ion (NH4) treated exactly as the sample.
Substances Darkened by Sulfuric Acid Dissolve 0.5 g in 5 mL of sulfuric acid. Allow the solution to stand for 15 min. The color of the sample solution should not exceed that of an equal volume of the acid.
© 2017 American Chemical Society
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DOI:10.1021/acsreagents.4155.20160601 ACS Reagent Chemicals, Part 4
ACS Reagent Chemicals
Monograph
pubs.acs.org/doi/book/10.1021/acsreagents
Hydrolyzable Substances Boil 10 mL of a 1 in 10 solution of glycine for 1 min, and set aside for 2 h. The solution, when compared to an equal volume of an untreated sample solution, should appear as clear and as mobile.
© 2017 American Chemical Society
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DOI:10.1021/acsreagents.4155.20160601 ACS Reagent Chemicals, Part 4
