HYDRAZINE DERIVATIVES Think of them as
diuretic trademarked DIAMOX®. By Lately hydrazine derivatives adding benzyl chloride and methyl have drawn considerable attention iodide to the reaction, Lederle profrom research scientists. To find out duced methazolamide, a carbonic which derivatives have received the closest scrutiny, we went to our anhydrase inhibitor trademarked unique hydrazine Databank. NEPTAZANE.® If you react any of these derivaIt promptly gave us a breakdown tives with your imagination, who of patents by application and derivative class over five years, 1977 knows what commercial success through 1981. (See chart.) you might find? As the nation's number one marThe chain gang keter of hydrazine, our interest is If you're looking for chain extenmore than mere idle curiosity. Our ders or cross-linkers, you should be hydrazine has been the starting looking atdihydrazides. Oxalic, sucpoint for many of these derivatives. cinic, adipic and sebacic dihydraAnd our technology has helped lay zides have the general formula the foundation for the development 0 0 of many of their end products. H2NNHC(CH2)nCNHNH2 But we've observed that many prefer to buy the derivatives readywhere n may be 0,2,4 or 8. Anmade. There are good reasons: other dihydrazide, isophthalic, To save production steps. To free looks a bit different, with the hycapacity for other uses. Or to get drazide groups occupying the 1 the ease, convenience and safety and 3 positions of the benzene of handling hydrazine as a solid ring. In all of the dihydrazides (which almost all its derivatives the NH2 groups are highly reacare.) tive. There's enough of a range of properties here that the So we've also become a leadchances are good at least one ing supplier of hydrazine derivaof them will give you exactly the tives. If you've been hesitant so link you've been searching for. far to make your own, there's Hydrazides 1 9 4 5 1 6 2 3 15 5 60 Let's get started never been a better time to get in 1,3,4-Thiadiazoles 8 9 4 1 1 3 31 9 6 7 88 on all this successful research Besides those already disOther Sulfur Q 4 pp q s S7 14 action. Here are a few ideas from cussed, we can supply a broad Derivatives 1 4 - 3 4 22 9 - 5 - 5 / our Databank to get you started. Pyrazoles 6 10 4 2 2 — 24 range of other hydrazine derivaTry 1,2,4-triazole for starters 1,2,4-Triazole 12 1 — 10 14 4 2 2 10 55 tives — hydrazines, trihydraAs the chart shows, one of the "hot- Carbohydrazide 3 1 — 1 — 1 — 3 — 9 zides, special hydrazides (cartest" hydrazine derivatives is 1,2,4- Semicarbazide -, 0 o 1 1 OA bohydrazide, semicarbazide ir> i 1^—1 ^
