Nanoscience and Nanotechnology at UCLA | ACS Nano

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Nanoscience and Nanotechnology at UCLA

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his year, the University of California, Los Angeles (UCLA) celebrates its centennial. We join in this celebration with a virtual issue of ACS Nano featuring research and ideas from UCLA faculty and our collaborators around the world.1 UCLA hosts one of the world’s major nano centers, the California NanoSystems Institute (CNSI),2 which is a partnership between UCLA, UC Santa Barbara, and the University of California (UC) system. Key to the success of interdisciplinary research, including nanoscience and nanotechnology, at UCLA is its compactnesswhile UCLA is the largest of the UC campuses by any measure of population, it is also the smallest by area. Around one courtyard, the Court of Science, are all of engineering, all of science, medicine, CNSI, and the Institute of the Environment. Within one block are the School of Public Health, all of neuroscience, and the top hospital in the region. Faculty, students, and staff from science, engineering, medicine, and beyond see each other frequently, share problems and approaches, and we work together.

The California NanoSystems Institute at UCLA brings together science, engineering, medicine, art, film, law, public health, public policy, and entrepreneurship with faculty, students, staff, and industrial partners. Image credit Brad Feinknopf.

Faculty, students, and staff from science, engineering, medicine, and beyond see each other frequently, share problems and approaches, and we work together.

neurotechnology,8−10 microbiome studies,11 nano applications in energy, environmental, and sustainability issues,26−32 the future of electronics,28−34 the future of imaging,5,12 the intersection of nanoscience and art, and many more. All of the above areas are represented by one or more centers that cross academic disciplines at UCLA and elsewhere. For example, our three editors at UCLA collaborate broadly and serve as leaders across campus and internationally. Ali Khademhosseini is a world leader in tissue engineering; he founded and directs the Center for Minimally Invasive Therapeutics, which targets medical issues with nanotechnology solutions.35,36 Andre Nel is the founding head of the Division of Nanomedicine in the David Geffen School of Medicine and is an international leader in nano environmental health and safety, serving as founder and director of the UC Center for the Environmental Implications of Nanotechnology.37 Paul Weiss led CNSI, a W.M. Keck Foundation Center on Leveraging Sparsity, applying ideas from mathematics to imaging of all modalities, and a center on electrogenic biofilms, and is now leading the Challenge Initiative at UCLA. Our faculty have had leadership roles in proposing and in developing the technology roadmaps for the BRAIN Initiative and the U.S. Microbiome Initiative, both of which were published in ACS Nano.8,11 We have also had leading roles in developing new approaches to nano environmental health and safety and have led many of the discussions on how these approaches can be adopted nationally and internationally.38,39 As one of the leading universities of the world, and a public university, we see many students who are the first in their

Another driving force for UCLA is being surrounded by and collaborating with the entertainment industry in west Los Angeles. There is tremendous creative pressure to do something extraordinary in life and in the laboratory, and we see the results in our science. We also engage with our colleagues (stay tuned for an upcoming exhibition at the London Science Museum) and through the Science Entertainment Exchange,3 a collaboration with the Directors Guild of America and the National Academy of Sciences. When CNSI was established, 15 new faculty lines in nanoscience and nanotechnology were added, with the number eventually growing to 23 (so far). From the point of view of the state of California, the mission of CNSI (and its three sister institutes in other fields on other UC campuses) was to enable strong interactions with industry large and small as well as to enable global leadership in our field(s).2 The 180,000 square foot building opened in 2007 and continues to be renewed through new faculty, students, staff, ideas, centers, symposia, and partnerships. The Institute has served as the temporary home to many visitors from around the world, including a large number of ACS Nano authors, advisors, and editors. Over 2000 users come for the facilities at CNSI, and an incubator and support structure currently house 17 startups, with many previously “graduating” from this program. Focal points for UCLA and CNSI include biomedical capabilities enabled by nanoscience and nanotechnology,4−21 nano environmental health and safety,22−25 neuroscience and © 2019 American Chemical Society

Published: June 25, 2019 6127

DOI: 10.1021/acsnano.9b04680 ACS Nano 2019, 13, 6127−6129

Editorial

Cite This: ACS Nano 2019, 13, 6127−6129

ACS Nano

Editorial

Nanoscience and nanotechnology have served as cohesive forces around the world and especially at UCLA.

Sarah H. Tolbert, Professor

Tian Xia, Associate Professor

families to go to college (including about one-third of our undergraduates). Thus, we take special pleasure in introducing them and our other students to the worlds of nanoscience and nanotechnology.40 A fully subscribed program for elementary, middle, and high school teachers at CNSI introduces nanoscience and nanotechnology to classrooms throughout southern California. This program, together with many public science events, builds a network of teachers working together with UCLA students, postdoctoral fellows, and faculty to improve nanoscience education. We leverage our contacts in the entertainment industry to help define nanoscience and nanotechnology and the goals of our work for the public. Nanoscience and nanotechnology have served as cohesive forces around the world and especially at UCLA. We are looking forward to new initiatives, programs, and impact in our second century.

Jeffrey I. Zink, Distinguished Professor



Paul S. Weiss,* Editor-in-Chief AUTHOR INFORMATION

Corresponding Author

*E-mail: [email protected]. ORCID

Ali Khademhosseini: 0000-0002-2692-1524 Andre E. Nel: 0000-0002-5232-4686 Holly Bunje: 0000-0002-3085-9890 Christopher J. DeSantis: 0000-0002-4769-7541 Anne M. Andrews: 0000-0002-1961-4833 Rita A. Blaik: 0000-0003-3449-8882 Zhen Gu: 0000-0003-2947-4456 Huan Meng: 0000-0001-8844-3938 Aydogan Ozcan: 0000-0002-0717-683X Sarah H. Tolbert: 0000-0001-9969-1582 Tian Xia: 0000-0003-0123-1305 Jeffrey I. Zink: 0000-0002-9792-4976 Paul S. Weiss: 0000-0001-5527-6248

Ali Khademhosseini, Associate Editor

Andre E. Nel, Associate Editor

Notes

Views expressed in this editorial are those of the authors and not necessarily the views of the ACS.

Holly Bunje, ACS Nano Communications



REFERENCES

(1) https://pubs.acs.org/page/ancac3/vi/ucla100.html. (2) https://cnsi.ucla.edu/ (accessed June 10, 2019). (3) http://scienceandentertainmentexchange.org/ (accessed June 10, 2019). (4) Zhang, H.; Ji, Z.; Xia, T.; Meng, H.; Low-Kam, C.; Liu, R.; Pokhrel, S.; Lin, S.; Wang, X.; Liao, Y.-P.; Wang, M.; Li, L.; Rallo, R.; Damoiseaux, R.; Telesca, D.; Mädler, L.; Cohen, Y.; Zink, J. I.; Nel, A. E. Use of Metal Oxide Nanoparticle Band Gap To Develop a Predictive Paradigm for Oxidative Stress and Acute Pulmonary Inflammation. ACS Nano 2012, 6, 4349−4368. (5) Liong, M.; Lu, J.; Kovochich, M.; Xia, T.; Ruehm, S. G.; Nel, A. E.; Tamanoi, F.; Zink, J. I. Multifunctional Inorganic Nanoparticles for Imaging, Targeting, and Drug Delivery. ACS Nano 2008, 2, 889−896. (6) Meng, H.; Liong, M.; Xia, T.; Li, Z.; Ji, Z.; Zink, J. I.; Nel, A. E. Engineered Design of Mesoporous Silica Nanoparticles to Deliver Doxorubicin and P-Glycoprotein siRNA to Overcome Drug Resistance in a Cancer Cell Line. ACS Nano 2010, 4, 4539−4550. (7) Meng, H.; Mai, W. X.; Zhang, H.; Xue, M.; Xia, T.; Lin, S.; Wang, X.; Zhao, Y.; Ji, Z.; Zink, J. I.; Nel, A. E. Co-Delivery of an Optimal Drug/siRNA Combination Using Mesoporous Silica Nanoparticle to Overcome Drug Resistance in Breast Cancer in Vitro and in Vivo. ACS Nano 2013, 7 (2013), 994−1005. (8) Alivisatos, A. P.; Andrews, A. M.; Boyden, E. S.; Chun, M.; Church, G. M.; Deisseroth, K.; Donoghue, J. P.; Fraser, S. E.; Lippincott-Schwartz, J.; Looger, L. L.; Masmanidis, S.; McEuen, P. L.; Nurmikko, A. V.; Park, H.; Peterka, D. S.; Reid, C.; Roukes, M. L.;

Christopher J. DeSantis, Managing Editor

Anne M. Andrews, Professor and ACS Chemical Neuroscience Associate Editor

Rita A. Blaik, CNSI Manager of Education

Zhen Gu, Professor

Huan Meng, Assistant Professor Aydogan Ozcan, Chancellor’s Professor and Editorial Advisory Board 6128

DOI: 10.1021/acsnano.9b04680 ACS Nano 2019, 13, 6127−6129

ACS Nano

Editorial

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DOI: 10.1021/acsnano.9b04680 ACS Nano 2019, 13, 6127−6129