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Article
Placental metal concentrations in relation to maternal and infant toenails in a US cohort Tracy Punshon, Zhigang Li, Carmen Marsit, Brian P. Jackson, Emily R Baker, and Margaret Karagas Environ. Sci. Technol., Just Accepted Manuscript • DOI: 10.1021/acs.est.5b05316 • Publication Date (Web): 04 Jan 2016 Downloaded from http://pubs.acs.org on January 10, 2016
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Environmental Science & Technology
Maternal post-partum toenails N=565
Placenta N=750
Cd Pb Hg Mn Se Zn
Infant toenails N=360 ACS Paragon Plus Environment
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Placental metal concentrations in relation to maternal and infant toenails in a US cohort
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Tracy Punshon*1, Zhigang Li2, Carmen J. Marsit2, Brian P. Jackson2, Emily R. Baker3 and Margaret R.
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Karagas2
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Running head: Metals in placenta
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1
Dartmouth College, Department of Biology, 78 College Street, Hanover, NH, 03755
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2
Geisel School of Medicine, Dartmouth College, Hanover, NH, 03755
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Dartmouth Hitchcock Medical Center, Department of Obstetrics and Gynecology, One Medical Center
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Drive, Lebanon, NH, 03756
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*Address correspondence and reprint requests to:
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Tracy Punshon, PhD
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Research Assistant Professor
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Department of Biology, Dartmouth College
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78 College Street
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Hanover, NH 03756
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Tel: (603) 646 1037
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Fax: (603) 646 1347
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[email protected] 22 23
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ABSTRACT
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Metal contaminants cross the placenta, presenting a heightened risk of perturbing fetal development.
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Information on placental concentrations and transfer of multiple potentially toxic metals from low to
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moderate exposure is lacking. We measured concentrations of Cd, Pb, Hg Mn, Se and Zn in 750 placentas
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collected from women enrolled in the New Hampshire Birth Cohort Study and examined the correlation
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between elements, and profiles of potentially toxic metals (Cd, Pb, Hg and Mn) stratified by nutrient
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concentrations (Zn and Se) using Principal Components Analyses (PCA). We further examined the indirect
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effects of maternal metal concentrations on infant metal concentrations through placenta metal
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concentrations using structural equation models. Placental metal concentrations were all correlated,
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particularly Zn and Mn, and Zn and Cd, and the principal component of metals differed by stratum of high
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versus low Zn and Se. Associations were observed between placenta and maternal toenail Se (β 63.49,
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P
