Stereoselective Hydrocoupling of Cinnamic Acid Esters by

From the resulting hydrodimers, (3R,4R)-3,4-diaryladipic acid esters and (3R,4R)-3 ... Synthetic Organic Electrochemical Methods Since 2000: On the Ve...
0 downloads 0 Views 261KB Size
Stereoselective Hydrocoupling of Cinnamic Acid Esters by Electroreduction: Application to Asymmetric Synthesis of Hydrodimers Naoki Kise,* Shumei Iitaka, Keisuke Iwasaki, and Nasuo Ueda Department of Biotechnology, Faculty of Engineering, Tottori University, Koyama, Tottori 680-8552, Japan [email protected] Received July 11, 2002

The electroreduction of Ar-substituted methyl cinnamates in acetonitrile gave all-trans cyclized hydrodimers stereoselectively (58∼90% de). In all cases, small amounts (