Symposium on Advanced Analytical Concepts for ... - ACS Publications

Mar 16, 1978 - technical program includes three ses- sions entitled Advanced ... Friday Morning,Mar. 17. 9:00. Polychromatic Analysis: New. Applicatio...
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The building in the background houses the Oak Ridge Isochronous Cyclotron

Oak Ridge National Laboratory (ORNL) will host the 10th Annual Symposium on Advanced Analytical Concepts for the Clinical Laboratory at Oak Ridge, Tenn., on March 16-17, 1978. The symposium is jointly sponsored by ORNL, the National Institute of General Medical Sciences, the Department of Energy, and the Academy of Clinical Laboratory Physicians and Scientists. This symposium series, held annually at Oak Ridge National Laboratory, was established in 1969 to provide a forum for discussion of recent developments in the application of analytical concepts to clinical analysis. The technical program includes three sessions entitled Advanced Concepts,

Symposium on Advanced Analytical Concepts for the

Clinical Laboratory Oak Ridge, Tenn. March 16-17, 1978

Accelerator

Analytical Systems, and Future Trends in Advanced Analytical Concepts. The nineteen papers scheduled at these sessions represent new ideas or new technology with a potential for application for the clinical laboratory. The highlight of the meeting will be the final session on Future Trends in Advanced Analytical Techniques. In this session a series of emerging analytical techniques will be analyzed and discussed, with predictions for future developments and ultimate utility in the clinical laboratory. All attendees are invited to a social hour and dinner on Thursday evening, March 16. The proceedings will be published as a single issue of Clinical Chemistry. The detailed program follows.

PROGRAM Thursday Morning, Mar. 16

Session I: Advanced Concepts Chairman: D. C. Cannon, U of TexasHouston 9:30 Introduction. C. D. Scott, ORNL 9:45 Cell Electrophoresis Applied to Immunologic Research. P. Blume, A. Malley, R. J. Knox, G. V. F. Seaman, Good Samaritan Hospital 10:10 Separation and Analysis of Arylsulfatase Isoenzymes in Body Fluids of Man. W. D. Bostick, S. R. Dinsmore, J. E. Mrochek, ORNL 10:35 Intermission 11:00 High-Performance Liquid Chromatographic Separation and Quantitation of Biogenic Amines in Plasma and Tissue. T. P. Davis, C. W. Gehrke, T. D. Cunningham, K. O. Gerhardt, K. C. Kuo, C. W. Gehrke, Jr., U of Missouri-Columbia 11:25 New Quantitative Ultramicro Immunoenzymatic Method: Measurement of Ig Antigenic De-

terminants at Single Cell Level. P. Hosli, S. Avrameas, Institut Pasteur, France 11:50 Melting Point of Gallium Apparatus for Thermometer Calibration. P. Dudek, Yellow Springs Instruments Co.

3:05 Automated System for Fractionation of Blood Samples. Ν. Ε. Lee, R. K. Genung, J. E. Mrochek, C. D. Scott, ORNL 3:30 Development and Evaluation of Glucose Analyzer for GlucoseControlled Insulin Infusion System. E. J. Fogt, L. M. Dodd, E. M. Jenning, A. H. Clemens, Miles Labs

Thursday Afternoon, Mar. 16 1:45 Multilayer Film Elements for Clinical Analysis: General Principles. H. G. Curme, Eastman Kodak Co. 2:10 Multilayer Film Elements for Clinical Analysis: Applications to Representative Chemistries. R. W. Spayd, Eastman Kodak Co.

Session II: Analytical Systems Chairman: J. C. Sternberg, Beckman Instruments 2:40 Isoenzyme Analysis by HPLC. T. D. Schlabach, A. Alpert, F. E. Régnier, Purdue U

Friday Morning, Mar. 17 9:00 Polychromatic Analysis: New Applications of an Old Technique. B. Hahn, D. Vlastelica, L. Snyder, Technicon Instruments Corp. 9:25 Rapid, Dual-Column IonExchange Chromatography of βAIBA and /3-Ala in Physiological Fluids. T. F. Cole, K. C. Kuo, C. W. Gehrke, U of Missouri-Columbia 9:50 Improved Approach to Se­ quential Addition Immunoassay. F. D. Lasky, A. Karmen, J. AlRazi, Al­ bert Einstein College of Medicine 10:15 Intermission

ANALYTICAL CHEMISTRY, VOL. 50, NO. 3, MARCH 1978 · 343 A

News are in electrochemistry and in thermo­ chemistry. Dr. Jordan is a member of the Editorial Board of Analytical Let­ ters and has also served on the Advi­ sory Boards of ANALYTICAL CHEMIS­ TRY and Talanta. He is a fellow of the American Association for the Ad­ vancement of Science and of the American Institute of Chemists, and a senior member of the Faraday Soci­ ety.

Session III: Future Trends in Advanced Analytical Concepts Chairman: W. H. C. Walker, McMaster U, Canada 10:45 Determination of Psychoac­ tive Drug Blood Levels by HighPerformance Thin-Layer Chroma­ tography. D. C. Fenimore, C. J. Meyer, C. M. Davis, Texas Medical Center 11:15 Coupled Reactions of Immo­ bilized Enzymes and Immobilized Substrates: Clinical Applications. M. H. Keyes, R. C. Barabino, D. N. Gray, Owens-Illinois 11:45 Fluorescence and Enzyme Immunoassays for Enzyme and Bacterial Antigens in the Clinical Laboratory. B. W. Papermaster, J. E. McEntire, P. D. Sandefur, U of TexasGalveston Friday Afternoon, Mar. 17 1:45 Advances in Cytochemical Hormone Analysis. L. Bitensky, Kennedy Institute of Rheumatology, UK 2:15 New Liquid Chromatograph­ ic Techniques of Potential Interest to the Clinical Laboratory. J. E. Mrochek, W. D. Bostick, S. R. Dinsmore, ORNL 2:45 Applications of Calorimetry in the Clinical Laboratory. Ν. Ν. Rehak, D. S. Young, NIH 3:15 Closing Remarks. R. S. Mel ville, National Institute of General Medical Sciences

AOAC Invites Nominations for Harvey W. Wiley Award

Joseph

Jordan

to the U.S. in 1950 as a research fellow with J. J. Lingane at Harvard. From 1951 to 1954 he was associated with I. M. Kolthoff at the University of Minnesota. In the autumn of 1954, Professor Jordan joined the faculty of Pennsylvania State University as assistant professor. He was promoted to associate professor in 1957 and to full professor in 1960. He has over 100 publications including chapters and sections in treatises and reference books. His primary areas of interest

The Association of Official Analyti­ cal Chemists (AOAC) invites nomina­ tions for the 22nd AOAC Harvey W. Wiley Award for outstanding contri­ butions to analytical methodology im­ portant to government regulatory agencies. AOAC established the $750 annual award in 1956 to honor Harvey W. Wiley, "Father of the Pure Food and Drug Act" and also a founder of the AOAC. The purpose of the award is to recognize an outstanding scientist or scientific team for contributions to analytical methodology in areas per­ taining to agriculture and public health. Topics include foods, drugs, pesticides, cosmetics, feeds, fertilizers, beverages, colors, forensic science ma­ terials, hazardous substances, vita-

1978 Benedetti-Pichler Award For his outstanding contribution to microchemistry, Joseph Jordan of Pennsylvania State University has been named to receive the 1978 Ben­ edetti-Pichler Award. The award will be presented at the 5th Annual Meet­ ing of the Federation of Analytical Chemistry and Spectroscopy So­ cieties, to be held in Boston, October 30-November 2,1978. The award, sponsored by the American Microchemical Society, is given annually in recognition of services to microchem­ istry in its broadest meaning, which includes research, application, admin­ istration, teaching, or other means of promoting the advancement of microchemistry. Professor Jordan was born in Ru­ mania in 1919. He earned his doctor­ ate degree in chemistry at the Hebrew University, Jerusalem, Israel, in 1945 and worked there until 1950. He came

The fluorescent properties of many antitumor drugs make fluorescence spectromet­ r y analysis particularly valuable in tracing the drugs from the distribution stage in the body, through the metabolic stage, to eventual elimination. As a part of the National Cancer Institute's $800-million-a-year cancer research program, the BioMolecular Sciences Section of Arthur D. Little Inc., is monitoring the metabolic distribution of anticancer drugs by fluorescence analyses. In the photo, a sample of antitumor drug metabolite is placed into the cell of a Perkin-Elmer fluorescence spectrophotometer by Marianne Callahann of Arthur D. Little Inc.

344 A · ANALYTICAL CHEMISTRY, VOL. 50. NO. 3, MARCH 1978

News mins, water and air pollutants, microbiological and extraneous material contamination of foods and drugs, and general analytical chemistry. T h e 1977 award was presented to Gunter Zweig, Environmental Protection Agency, Washington, D.C., for his outstanding contributions to the analysis of pesticide residues. For nomination forms and further information, contact Luther G. Ensminger, AOAC, Box 540, Benjamin Franklin Station, Washington, D.C. 20044. Nominations must be received by April 1,1978.

AOAC Membership Drive "Are you a member of the AOAC? Can you prove i t ? " With this banner, the Association of Official Analytical Chemists (AOAC) has launched an unprecedented membership promotion campaign. Starting in 1978, membership in AOAC is no longer amorphous. Members were so informed by the president of the association, William W. Wright, at the general session of AOAC's 91st Annual Meeting held in Washington, D . C , October 17-20, 1977. In his President's Address, Mr. Wright outlined the new card-carrying membership plan in which all members are entitled to a subscription to the bimonthly AOAC newsletter, The Referee. Through the newsletter, members will have contact with the hundreds of other regulatory scientists working on methods validated through the AOAC process. Exceptions to the mandatory dues ($10) are to be made, however, for General and Associate Referees, committee members, and other appointed officials. All potential members are asked to fill out a membership application, which is intended to supply contact information as well as to pinpoint areas of scientific interest.

Oceanographers Study Oceanic Processes by On-Line Analyses Oceanographers have unique problems in analytical areas. Sampling is a difficult problem both because of small sample size in relation to the ocean volume and because of possible contamination of samples—even changes in samples from possible adsorption of constituents on container walls. Not the least of the oceanographers' difficulties is connected with doing analyses at sea while moving, according to Alberto Zirino, Cesar Clavell, Jr., and Peter F. Seligman of the Naval Ocean Systems Center (NOSC) in San Diego, Calif.

Nevertheless, today's marine chemists are able to take advantage of some of the newer analytical methods to study oceanic processes. Researchers envision ocean-going vessels equipped with microprocessor-controlled and minicomputer-automated atomic absorption units and chromatographs, for instance. A new level of sophistication in instrumentation permits real-time analyses. In sampling, tubular designed samplers can be placed "on-line" and tap into a continuous source of seawater. An example of underway sampling and automated instrumentation is afforded by an automated trace metal analyzer developed at NOSC. T h e unit measures Zn, Cu, Pb, and Cd in seawater by anodic stripping voltammetry. This system has been used to measure trace metals from a small vessel in several locations including San Diego Bay. It was observed t h a t Zn concentration fluctuated regularly with the tidal period. This was attributed to the fact t h a t relatively metalfree open ocean water moved into the bay at flood tide, while relatively polluted bay water was sampled during low tide. Conventional single measurements might not have given this result. Similarly, measurements while underway of surface pH, temperature, and chlorophyll-a fluorescence (an indicator of plants) near a discharge of a thermoelectric plant in the east loch of Pearl Harbor provided information t h a t might have been missed with conventional sampling. T h e higher acidity of discharged water is detectable in the pH, which decreases rapidly from an ambient 8.4 to 8.3. West of the discharge the fine structure in the pH profile clearly matches the detail in the chlorophyll-a profile. This occurs because plankton removes CO2 from the water during photosynthesis and raises the ambient pH. Similarly, the absence of an increase in pH corresponding to the large phytoplankton patch east of the power plant suggests t h a t photosynthesis may have been depressed by the extraneous warm water. With these systems and others, much can be learned about biologically active areas.

Fluorocarbon-11 in Seawater A team of researchers at the Naval Research Laboratory has been at work developing an analytical method for the determination of fluorocarbon-11 (trichlorofluoromethane, CC1;)F), a compound familiar to everyone. Their

concern, however, was not with the depletion of the ozone layer, as one might expect. Their aim was to monitor the movement of water-mass by measuring the a m o u n t of fluorocarbon-11 that has settled into the world's oceans. According to William Smith, the team's principal investigator, fluorocarbon-11 is an excellent tracer for the study of water-mass movements because the compound is essentially inert at the surface of the earth, has known sources, and can be measured at extremely low concentrations. And since the compound enters the ocean from the atmosphere, it is equally useful as a tracer of atmospheric mixing. In the shipboard analytical method developed by the team, the fluorocarbon-11 gas dissolved in a 25-mL sample is stripped from the ocean water sample by a carrier gas and transported directly into a gas chromatograph. There, the CC1;JF is separated from other gases and measured by an electron-capture detector. T h e small sample size and shipboard analysis of the CCl;sF measurements permit multiple replication. T h e accuracy of these analyses depends on adequate calibration at extremely low concentrations of CCI3F. Smith has developed a novel, two-stage gas-permeation technique for providing accurately known calibration mixtures in the concentration range of 2-200 parts per trillion by volume. They used the CCI3F method to trace the sinking and southward migration of cold water from arctic areas of the North Atlantic Ocean. Results were in agreement with those obtained by a much more elaborate radiochemical tracer method, used at other laboratories, which requires careful chemical purification and preconcentration for a period of three weeks prior to measurement of the tritium radioactivity.

Meetings • A S T M Symposium on Computer Information Handling in Clinical Laboratories. Mar. 8. Cleveland Convention Center, Cleveland, Ohio. Contact: Robert Megargle, Dept. of Chemistry, Cleveland State University, Cleveland, Ohio 44115 • 175th A C S National Meeting. Mar. 12-17. Anaheim, Calif. Contact: A. T. Winstead, ACS, 1155 16th St., N.W., Washington, DC. 20036 • 10th Annual Symposium on Advanced Analytical Concepts for

ANALYTICAL CHEMISTRY, VOL. 50, NO. 3, MARCH 1978 · 347 A

News the Clinical Laboratory. Mar. 16-17. Oak Ridge National Labora­ tory. Contact: Charles D. Scott, As­ sociate Director, Chemical Tech­ nology Div., Oak Ridge National Laboratory, P.O. Box X, Oak Ridge, Tenn. 37830. Page 1136 Α, Νου. • 2nd Annual Workshop on Indus­ trial Toxicology. Mar. 28-31. Thomas Jefferson U., Philadelphia. Contact: Dean R. C. Baldridge, Col­ lege of Graduate Studies, Thomas Jefferson U., Philadelphia, Pa. 19107 • Technicon Symposia. Mar. 29-31, Houston, Tex.; May 1-2, Montreal, Canada; May 4-5, Toronto, Canada; May 15-16, Vancouver, Canada. The symposia include presentations of papers discussing the latest tech­ niques in automated laboratory procedures and an exhibit of Technicon's new instruments. Contact: Technicon Corp., Tarrytown, Ν. Υ. 10591 • 1st European Conference on Op­ tical Systems & Applications. Apr. 4-6. Brighton, UK. Contact: Institute of Physics, 47 Belgrave Sq., London SW1X 8QX, UK m ACS 12th Middle Atlantic Re­ gional Meeting. Apr. 5-7. Hunt Valley Inn, Hunt Valley, Md. Con­ tact: F. Gornick, Dept. of Chemis­ try, U. of Maryland, Baltimore, Md. 21228 • 8th Annual Symposium on the Analytical Chemistry of Pollu­ tants. Apr. 5-7. Geneva, Switzer­ land. Contact: Congress Secretari­ at, P.O. Box 182, CH-4013, Basle, Switzerland. Page 708 A, July • International Conference on Computers and Optimization in Analytical Chemistry. Apr. 5-7. Amsterdam, The Netherlands. Con­ tact: Secretary, Computers and Optimization in Analytical Chem­ istry, Laboratory for Analytical Chemistry, Nieuwe Achtergracht 166, Amsterdam, The Netherlands m 9th Materials Research Sympo­ sium on Trace Organic Analysis: A New Frontier in Analytical Chemistry. Apr. 10-13. Gaithersburg, Md. Sponsored by the Na­ tional Bureau of Standards. Con­ tact: Stephen Chesler or Harry Hertz, Chemistry Bldg., Room A105, National Bureau of Stan­ dards, Washington, D.C. 20234. 301-921-2153. Page 708 A, July • Symposium on HPLC with Ap­ plication to the Pharmaceutical and Food Industries. Apr. 10-14. Sunderland, England. Contact: R. Dennis, School of Pharmacy, Sun­ derland Polytechnic, Chester Rd.,

Sunderland, Tyne & Wear, SRI 3SD, England • 7th International Geochemical Exploration Symposium. Apr. 16-20. Golden, Colo. Sponsored by the Association of Exploration Geochemists. Contact: M. A. Chaffee, Secretary, 7th IGES, U.S. Geologi­ cal Survey, 5946 Mclntyre St., Golden, Colo. 80401 • 12th International Symposium on Remote Sensing of Environ­ ment. Apr. 17-19. Philippines. Con­ tact: Environmental Research In­ stitute of Michigan, P.O. Box 8616, Ann Arbor, Mich. 48107 • Scanning Electron Microscopy Symposium. Apr. 17-21. Bonaventure Hotel, Los Angeles. Contact: Om Johari, Director, SEM Sympo­ sia, 1420 Β Volid Dr., Hoffman Es­ tates, III. 60194 • Biennial Analytica 78 Exhibi­ tion. Apr. 18-22. Munich. Contact: Kallman Associates, Munich Fair Authority, 30 Journal Sq., Jersey City, N.J. 07306 m Electrophoresis '78. Apr. 20-21. Cambridge, Mass. Sponsored by Massachusetts Institute of Technol­ ogy. Contact: N. Catsimpoolas, MIT, Room 56-307, Cambridge, Mass. 02139 • Canadian Chromatography Con­ ference. Apr. 27-28. Hotel Bonaventure, Montreal, Ontario. Con­ tact: V. M. Bhatnagar, P.O. Box 1779, Cornwall, Ont. K6H5V7, Canada • Computers in Activation Analy­ sis and Gamma-Ray Spectrosco­ py. Apr. 30-May 3. Mayaguez, Puerto Rico. Sponsored by Divi­ sions of American Nuclear Society, American Chemical Society, and NBS; ERDA; and U. of Puerto Rico. Contact: B. S. Carpenter, Reactor Bldg. 235, National Bureau of Standards, Washington, D.C. 20234 • 3rd Annual Regional Spring Training Conference and Exhi­ bition of AOAC. May 1-3. Mar­ riott Hotel, Atlanta. Contact: Sol Cohen, Assistant Director for Re­ search and Instrumentation, FDA, 60 Eighth St., N.E., Atlanta, Ga. 30309. 404-881-2131 • Seminar on Ionizing Radiation Measurement. May 9-12. National Bureau of Standards, Washington, D.C. Contact: Ε. Η. Eisenhower, Center for Radiation Research, NBS, Washington, D.C. 20234 • 69th Annual Meeting of Ameri­ can Oil Chemists' Society. May 14-18. Chase Park Plaza Hotel, St. Louis. Contact: George Willhite, JAOCS News, 508 S. Sixth St., Champaign, III. 61820

348 A · ANALYTICAL CHEMISTRY, VOL. 50, NO. 3, MARCH 1978

• 9th International Symposium on Chromatography and Electro­ phoresis. May 15-16. Riva Del Garda, Lake of Garda, Italy. Con­ tact: Alberto Frigerio, Istituto de Ricerche Farmacologiche, Mario Negri, Via Eritrea 62, 20157 Milan, Italy. Page 44 A, Jan. • Analytical Methods for Safe­ guard and Accountability Mea­ surements of Special Nuclear Materials. May 15-17. Williams­ burg, Va. Sponsored by Fuel Cycle Division and Virginia Section of American Nuclear Society, National Bureau of Standards, and Institute of Basic Standards. Contact: Ron L. Hoffmann, Babcock & Wilcox, LRC, P.O. Box 1260, Lynchburg, Va. 24505. Page 1020 A, Oct. • IMEKO Meeting on Application of Statistical Methods in Mea­ surement. May 17-19. Leningrad. Contact: IMEKO Secretariat, H1371 Budapest, POB 457, Hungary • 9th Annual Symposium and Short Courses on Applied Chro­ matography. May 18-19. Hilton Inn, Kenner, La. Sponsored by the Louisiana Section of ACS. Contact: Tom Pewitt, Shell Oil Co., P.O. Box 10, Norco, La. 70079 m 6th International CODATA Con­ ference. May 22-25. Taormina, Italy. Contact: CODATA Secretari­ at, 51 Blvd. de Montmorency, 75016 Paris, France • International Symposium on Nu­ clear Activation Techniques in the Life Sciences. May 22-26. Vienna, Austria. Contact: John H. Kane, Energy Research & Develop­ ment Administration, Washington, D.C. 20545 • ISA's Analysis Instrumentation Division Meeting. May 23-25. Stouffer's Greenway Plaza Motel, Houston, Tex. Contact: Thomas Puzniak, Gulf Science & Technolo­ gy Co., P.O. Box 2038, Pittsburgh, Pa. 15230. 412-362-1600. Page 1136 A, Nov. • International Symposium on the Analysis of Hydrocarbons and Halogenated Hydrocarbons in the Aquatic Environment. May 23-25. McMaster U., Hamilton, Ont., Canada. Organized by the Canada Centre for Inland Waters, Burlington, Ontario, and the Insti­ tute for Environmental Studies, U. of Toronto. Contact: Canada Cen­ tre for Inland Waters, P.O. Box 5050, Burlington, Ont., Canada L7R 4A6 • 3rd International Conference on Stable Isotopes. May 23-26. Oak Brook Hyatt House, Oak Brook, 111 Sponsored by Argonne National

News

















Laboratory. Contact: P. D. Klein, Div. of Biological and Medical Re­ search, Argonne National Labora­ tory, Argonne, III. 60439 ACS Joint 10th Central-12th Great Lakes Regional Meeting. May 24-26. Butler U., Indianapolis. Contact: R. Τ Rlickenstaff, Veter­ ans Administration Hospital, 1481 W. 10th St., Indianapolis, Ind. 26th Annual Conference on Mass Spectrometry and Allied Topics. May 28-June 2. Stouffer's River­ front Towers, St. Louis, Mo. Spon­ sored by American Society for Mass Spectrometry. Contact: Κ. Ε. McCulloh, A145, Chemistry Rldg., National Bureau of Standards, Washington, D.C. 20234 International Symposium on In­ strumental Applications in Fo­ rensic Drug Chemistry. May 2930. Ramada Inn, Rosslyn, Va. Spon­ sored by the Drug Enforcement Admin : stration, U.S. Department of Justice. Topics will include: appli­ cation of advanced techniques in in­ strumentation, computer applica­ tions, chromatographic advances, special topics on forensic drug anal­ ysis. Contact: Michael Klein, Spe­ cial Testing & Research Laborato­ ry, 7704 Old Springhouse Rd., McLean, Va. 22101 61st Canadian Chemical Confer­ ence and Exhibition. June 4-7. Convention Centre, Winnipeg, Man., Canada. Contact: The Chem­ ical Institute of Canada, 151 Slater St., Suite 906, Ottawa, Ont., Cana­ da KIP 5H3 4th ACS Rocky Mountain Re­ gional Meeting. June 6-8. U. of Colorado, Boulder. Contact: C. Pierpont, Dept. of Chemistry, U. of Colorado, Boulder, Colo. 80309 Microcomputer-Based Instru­ mentation Conference. June 1213. NBS, Gaithersburg, Md. Spon­ sored by NBS, IEEE Computer So­ ciety, IEE Group on Instrumenta­ tion and Measurement. Contact: Bradford Smith, A130 Technology Bldg., National Bureau of Stan­ dards, Washington, DC. 20234. 301-921-2381 33rd Annual Symposium on Mo­ lecular Spectroscopy. June 12-16. Ohio State U., Columbus, Ohio. Contact: K. Narahari Rao, Dept. of Physics, Molecular Spectroscopy Symposium, Ohio State U., 174 West 18th Ave., Columbus, Ohio 43210 2nd International Symposium on Quantitative Mass Spectrometry in Life Sciences. June 13-16. Rijksuniversiteit Gent, Belgium. Contact: A. De Leenheer, Sympo­

sium Chairman, Laboratoria voor Medische Biochemie en Klinische Analyse, de Pintelaan 135, B-9000 Gent, Belgium U ACS 33rd Northwest Regional Meeting. June 14-16. U. of Seattle. Contact: D. Thorsell, Chemistry Dept., Seattle U., Seattle, Wash. 98122 • 5th International Symposium on Mass Spectrometry in Biochem­ istry and Medicine. June 19-21. Rimini, Italy. Contact: Alberto Frigerio, Istituto de Ricerche Farmacologiche, Mario Negri, Via Eri­ trea 62, 20157 Milan, Italy. Page 44 A, Jan. • 13th Annual Microbeam Analysis Society Conference. June 19-23. Ann Arbor Inn, Ann Arbor, Mich. Contact: W. C. Bigelow, Dept. of Materials and Metallurgical Engr., U. of Michigan, Ann Arbor, Mich. 48104 • Symposium on Environmental Analytical Chemistry. June 2 1 23. Brigham Young U., Provo, Utah. Contact: Delbert J. Eatough, 271 FB, Thermochemical Institute, Brigham Young U., Provo, Utah 84602 U ACS 9th Northeast Regional Meeting. June 25-28. Simmons College, Boston. Contact: E. I. Becker, U. of Massachusetts, Har­ bor Campus, Boston, Mass. 02125 • ACS 31st Annual Summer Sym­ posium. June 26-28. Boulder, Colo. Sponsored by Analytical Chemistry Division. Contact: R. E. Siever, Dept. of Chemistry, U. of Colorado, Boulder, Colo. 80302 • 71st Annual Meeting of Air Pol­ lution Control Association. June 26-30. Houston, Tex. Contact: Pub­ lic Relations Dept., Air Pollution Control Assn., P.O. Box 2861, Pitts­ burgh, Pa. 15230. 412-621-1090 • ASTM Symposium on Some Im­ pediments to Analysis. June 2728. Boston. Contact: John E. Fos­ ter, Kawecki Berylco Industries, Inc., P.O. Box 567, Boyertown, Pa. 19512. Page 1022 A, Oct. • World Chromatography Confer­ ence. June 29-30. Sheraton Hotel, Stockholm, Sweden. Contact: F. M. Bhatnagar, P.O. Box 1779, Corn­ wall, Ont. K6H5V7, Canada m Micro-78. July 10-14. Bloomsbury Centre Hotel, London. Contact: The Royal Microscopical Society, 37/38 St. Clements, Oxford, OX4 1AJ, England • Gordon Research Conference on Electron Spectroscopy. July 1721. Wolfeboro, N.H. Contact: Charles S. Fadley, Dept. of Chem­

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istry, 2545 The Mall, U. of Hawaii, Honolulu, Hawaii 96822 • 6th Discussion Conference on Macromolecules: Chromatogra­ phy of Polymers and Polymers in Chromatography. July 17-21. Prague. Contact: P. M. M. Secre­ tariat, c/o Institute of Macromolecular Chemistry, 162 06 Prague 616, Czechoslovakia • 30th National Meeting of Ameri­ can Association for Clinical Chemistry. July 23-28. San Fran­ cisco. Contact: William J. Camp­ bell, AACC, 1725 Κ St., N. W., Washington, DC. 20006 m Inter/Micro-78. July 24-27. McCormick Inn, Chicago. Spon­ sored by McCrone Research Insti­ tute. Emphasis on new techniques in acoustic, infrared, interference microscopy; uses of laser Raman microprobe; techniques of modula­ tion contrast, and combinations of microscopes and computers. Con­ tact: McCrone Research Institute, 2508 S. Michigan Ave., Chicago, III. 60616. 312-842-7105 • 4th International Congress of Pesticide Chemistry. July 24-28. Zurich, Switzerland. Sponsored by the International Union of Pure and Applied Chemistry. Includes ses­ sions on pesticide residues. Contact: M. Spindler, Congress Secretariat, 4th International Congress of Pes­ ticide Chemistry, P.O. Box 182, CH-4013 Basle, Switzerland • 27th Denver Conference on Ap­ plications of X-ray Analysis. Aug. 1-4. U. of Denver. Emphasis on x-ray powder diffraction. Contact: Mildred Cain, Metallurgy and Ma­ terials Science Div., Denver Re­ search Institute, U. of Denver, Denver, Colo. 80208. 303-753-2141 • 20th Annual Rocky Mountain Conference on Analytical Chem­ istry. Aug. 7-9. Denver, Colo. Con­ tact: Daniel A. Netzel, Conference Chairman, Laramie Energy Re­ search Center, Box 3395, Universi­ ty Station, Laramie, Wyo. 82071. 307-721-2370. Page 1225 A, Dec. • 1978 Annual Symposium for In­ novation in Measurement Science. Aug. 20-25. Hobart and William Smith Colleges, Geneva, N.Y. Will include sessions on medi­ cal instrumentation, high precision measurement, petroleum industry, electronic innovations, chemical analysis, physical analysis, and en­ vironmental monitoring. Contact: Peter Vestal, Instrument Society of America, 400 Stanwix St., Pitts­ burgh, Pa.15222 m 8th IMEKO Symposium on Pho­ ton Detectors. Aug. 22-25. Prague

News Contact: Dipl.-Ing. Jiri Krâl, House of Technics, Gorkého nam., 23,11282 Praha 1, Czechoslovakia • 5th Biennial Conference of Australian and New Zealand Society for Mass Spectrometry. Aug. 28Sept. 1. U. of Queensland, Australia. Contact: D. C. Green, Dept. of Geology & Mineralogy, U. of Queensland, St. Lucia, Queensland 4067, Australia • 6th International Conference on Raman Spectroscopy. Sept. 4-9. Bangalore, India. Contact: J. R. Durig, College of Science & Mathematics, U. of South Carolina, Columbia, S.C. 29208. 803-777-2505 m 176th ACS National Meeting. Sept. 10-15. Miami Beach, Fla. Contact: A. T. Winstead, American Chemical Society, 1155 16th St., N.W., Washington, D.C. 20036 • 8th International Conference on Magnetic Resonance in Biological Systems. Sept. 11-14. Takayama, Japan. Contact: S. Fujiwara, Dept. of Chemistry, U. of Tokyo, Hongo, Tokyo 113, Japan m IMEKO Conference on Flow Measurement. Sept. 12-15. Groningen. Contact: FLOMEKO 1978, Groningen, POB 19, The Netherlands • 14th International Congress of the International Society for Fat Research. Sept. 17-22. Brighton, England. Includes sessions on analysis and characterization of lipids. Contact: ISF-78, Society of Chemical Industry, 14, Belgrave Square, London SW1X 8PS, England • 12th International Symposium on Chromatography. Sept. 25-29. Baden-Baden, Federal Republic of Germany. Jointly organized by the Chromatography Discussion Group, the Groupment pour l'Avancement des Méthodes Spectroscopique et Physicochimique d'Analyse, and the Arbeitskreis Chromatographie der Fachgruppe "Analytische Chemie" der Gesellschaft Deutscher Chemiker. Contact: Geschâftsstelle der Gesellschaft Deutscher Chemiker, Abteilung Fachgruppen, Postfach 900440, 6000 Frankfurt/ Main 90, Germany • Biological/Biomedical Applications of Liquid Chromatography. Oct. 5-6. Boston Park Plaza Hotel, Boston. 30 Papers and 40 poster presentations on use of liquid chromatography in peptides, amino acids, lipids, carbohydrates, drugs and drug metabolism, routine clinical applications and clinical research. Contact: Gerald L. Hawk, Symposium Chairman, International Div., Waters Associates, Inc.,

Milford, Mass. 01757. 617-478-2000 • 22nd Conference on Analytical Chemistry in Energy Technology. Oct. 10-12. Gatlinburg, Tenn. Contact: W. S. Lyon, Oak Ridge National Laboratory, P.O. Box X, Oak Ridge, Tenn. 37830 • 8th Annual Conference of North American Thermal Analysis Society. Oct. 15-18. Atlanta. Contact: W. E. Clark, Delco Products Div., GMC, P.O. Box 230, Rochester, Ν. Υ. 14601 • ISA/78. Oct. 15-19. Philadelphia. Contact: Instrument Society of America, 400 Stanwix St., Pitts­ burgh, Pa. 15222. Page 44 A, Jan. • 154th Meeting of the Electro­ chemical Society. Oct. 15-20. Pittsburgh. Contact: The Electro­ chemical Society, Inc., P.O. Box 2071, Princeton, N.J. 08540 • 92nd Annual Meeting of Associa­ tion of Official Analytical Chem­ ists. Oct. 16-19. Marriott Hotel, Twin Bridges, Washington, D.C. Contact: Luther G. Ensminger, AOAC, Box 540, Benjamin Frank­ lin Station, Washington, D.C. 20044 • 13th International Symposium on Advances in Chromatography. Oct. 16-19. Sheraton-St. Louis Hotel, St. Louis. Contact: A. Zlatkis, Chemistry Dept., U. of Hous­ ton, Houston, Tex. 77004 m 17th Annual Meeting of ASTM Committee E-19 on Practice of Chromatography. Oct. 22-25. At­ lanta, Ga. Contact: Gerald Dupre, Bio/Dynamics, Inc., Box 43, Mettlers Rd., East Millstone, N.J. 08873 • 3rd International Symposium on Polynuclear Aromatic Hydrocar­ bons. Oct. 25-28. Battelle Colum­ bus Labs, Ohio. Contact: Peter W. Jones, Battelle Columbus Labs, 505 King Ave., Columbus, Ohio 43201 • ACS 14th Midwest Regional Meeting. Oct. 26-27. U. of Arkan­ sas, Fayetteville. Contact T. D. Roberts, Dept. of Chemistry, U. of Arkansas, Fayetteville, Ark. 72701 • 5th Annual Meeting of the Fed­ eration of Analytical Chemistry and Spectroscopy Societies. Oct. 30-Nov. 3. Boston. Contact: Paul Lublin, GTE Laboratories, 40 Syl­ van Rd., Waltham, Mass. 02154. 617-890-8460. Page 44 A, Jan. m ACS 30th Southeastern Regional Meeting. Nov. 8-10. Savannah, Ga. Contact: J. G. Brewer, Dept. of Chemistry & Physics, Armstrong State College, Savannah, Ga. 31406 • Symposium on Pulsed Nuclear Magnetic Resonance in Solids. Dec. 18-19. Queen Elizabeth Col-

352 A · ANALYTICAL CHEMISTRY, VOL. 50, NO. 3, MARCH 1978

lege, U. of London. Contact: J.A.S. Smith, Dept. of Chemistry, Queen Elizabeth College, Campden Hill Rd., London, W8, UK

Short Courses ACS Courses. For more information, contact: Department of Educational Activities, American Chemical Soci­ ety, 1155 Sixteenth St., N.W., Wash­ ington, D.C. 20036. 202-872-4508 Thin-Layer Chromatography Cleveland. Mar. 3-4. Victor W. Rodwell and Donald J. McNamara. $195, ACS members; $235, nonmembers Solving Problems with Modern Liquid Chromatography Cleveland. Mar. 3-5. J. J. Kirkland and Lloyd R. Snyder. $225, ACS mem­ bers; $265, nonmembers Electroanalytical Chemistry Anaheim, Calif. Mar. 10-12. Dennis Evans and Paul Whitson. $225, ACS members; $305, nonmembers Carbon-13 NMR Spectroscopy Anaheim, Calif. Mar. 10-12. George Levy and Paul Ellis. $255, ACS mem­ bers; $305, nonmembers Modern Techniques in Gas Chro­ matography Anaheim, Calif. Mar. 11-12. Harold McNair and Stuart Cram. $195, ACS members; $235, nonmembers Statistics for Experimental Design Anaheim, Calif. Mar. 11-12. John Hromi. $195, ACS members; $235, nonmembers Solving Problems with Modern Liquid Chromatography Anaheim, Calif. Mar. 11-12. J. Kirk­ land and Lloyd Snyder. $225, ACS members; $265, nonmembers Effective Writing for Scientists and Engineers Anaheim, Calif. Mar. 15-17. Henrietta Tichy and Sylvia Fourdrinier. $225, ACS members; $275, nonmembers Thin-Layer Chromatography Anaheim, Calif. Mar. 16-17. Victor Rodwell and Donald McNamara. $195, ACS members; $235, nonmem­ bers Maintenance & Troubleshooting Chromatographic Systems Work­ shop Houston, Tex. Mar. 18-19, Apr. 21-22.