From the Editor 1155—16th St., N.W., Washington, DC 20036 (202) 872-4600 or (800) 227-5558 EDITOR-IN-CHIEF: Bibiana Campos Seijo EDITORIAL DIRECTOR: Amanda Yarnell PRODUCTION DIRECTOR: Rachel Sheremeta Pepling BUSINESS DEVELOPMENT & PUBLISHER: Kevin A. Davies SENIOR ADMINISTRATIVE OFFICER: Marvel A. Wills BUSINESS NEW YORK CITY: (212) 608-6306 Michael McCoy, Assistant Managing Editor, Rick Mullin (Senior Editor), Marc S. Reisch (Senior Correspondent), Alexander H. Tullo (Senior Correspondent), Rachel Eskenazi (Administrative Assistant). CHICAGO: (917) 710-0924 Lisa M. Jarvis (Senior Correspondent). HONG KONG: 852 9093 8445 Jean-François Tremblay (Senior Correspondent). HOUSTON: (281) 486-3900 Ann M. Thayer (Senior Correspondent). LONDON: 44 1494 564 316 Alex Scott (Senior Editor). WEST COAST: (315) 825-8566 Melody M. Bomgardner (Senior Editor) POLICY Cheryl Hogue, Assistant Managing Editor Britt E. Erickson (Senior Editor), Jessica Morrison (Associate Editor), Andrea L. Widener (Senior Editor) SCIENCE/TECHNOLOGY/EDUCATION WASHINGTON: Lauren K. Wolf, Assistant Managing Editor Celia Henry Arnaud (Senior Editor), Stuart A. Borman (Senior Correspondent), Ryan Cross (Contributing Editor), Matt Davenport (Associate Editor), Stephen K. Ritter (Senior Correspondent). BERLIN: 49 30 2123 3740 Sarah Everts (Senior Editor). BOSTON: (973) 922-0175 Bethany Halford (Senior Editor). CHICAGO: (847) 679-1156 Mitch Jacoby (Senior Correspondent). WEST COAST: (626) 765-6767 Michael Torrice (Deputy Assistant Managing Editor), (925) 226-8202 Jyllian Kemsley (Senior Editor), (510) 390-6180 Elizabeth K. Wilson (Senior Editor) JOURNAL NEWS & COMMUNITY: (510) 768-7657 Corinna Wu (Senior Editor) (651) 447-6226 Jessica H. Marshall (Associate Editor) ACS NEWS & SPECIAL FEATURES Linda Wang (Senior Editor) EDITING & PRODUCTION Kimberly R. Bryson, Assistant Managing Editor Craig Bettenhausen (Associate Editor), Taylor C. Hood (Contributing Editor), Manny I. Fox Morone (Associate Editor), Alexandra A. Taylor (Contributing Editor) CREATIVE Robert Bryson, Creative Director Tchad K. Blair, Interactive Creative Director Robin L. Braverman (Senior Art Director), Ty A. Finocchiaro (Senior Web Associate), Yang H. Ku (Art Director), William A. Ludwig (Associate Designer) DIGITAL PRODUCTION Renee L. Zerby, Manager, Digital Production Luis A. Carrillo (Web Production Manager), Marielyn Cobero (Digital Production Associate), Joe Davis (Lead Digital Production Associate), Krystal King (Lead Digital Production Associate), Shelly E. Savage (Senior Digital Production Associate), Cesar Sosa (Digital Production Associate) PRODUCTS MANAGER: Pamela Rigden Snead CONTENT MARKETING EDITOR: Mitch A. Garcia SALES & MARKETING Stephanie Holland, Manager, Advertising Sales & Marketing Natalia Bokhari (Digital Advertising Operations Manager), Kirsten Dobson (Advertising and Marketing Associate), Sondra Hadden (Senior Digital Marketing Specialist), Quyen Pham (Digital Advertising & Lead Generation Associate), Ed Rather (Recruitment Advertising Product Manager) ADVISORY BOARD Deborah Blum, Raychelle Burks, Kendrew H. Colton, François-Xavier Coudert, Cathleen Crudden, Paula T. Hammond, Matthew Hartings, Christopher Hill, Peter Nagler, Dan Shine, Michael Sofia, Michael Tarselli, William Tolman, James C. Tung, Jill Venton, Helma Wennemers, Geofrey K. Wyatt Published by the AMERICAN CHEMICAL SOCIETY Thomas M. Connelly Jr., Executive Director & CEO Brian D. Crawford, President, Publications Division EDITORIAL BOARD: Nicole S. Sampson (Chair), ACS Board of Directors Chair: Pat N. Confalone, ACS President: Donna J. Nelson, Cynthia J. Burrows, Michael P. Doyle, Jerzy Klosin, Gary B. Schuster Copyright 2016, American Chemical Society Canadian GST Reg. No. R127571347 Volume 94, Number 48
Wrapping up 2016 or many of us December is synonymous with Christmas. Dec. 1 marks the day when tree and decorations come out of the attic or basement to get us in the mood for the festivities later on in the month. But these days, in addition to the tinsel and lights, there’s another traditional feature that we have come to associate with the beginning of December: little red ribbons adorning coats and jackets everywhere. These ribbons represent a global red symbol of solidarity with those who are HIV-positive or living with AIDS. Dec. 1 is World AIDS Day, an event that was held for first time in 1988, a mere four years after the HIV virus was discovered. Since then, 36 million people worldwide have died of AIDS and another 35 million live with HIV, making it one of the most destructive pandemics in history. In this issue we commemorate World AIDS Day with a feature article that looks at a clinical trial that was recently launched in South Africa. It is the first trial in 7 years to test the efficacy of an HIV vaccine, so the stakes are high: The trial could yield the first licensed preventative HIV vaccine. Read more about it on page 18. We also dedicate a large portion of this issue to the first part of our annual Year in Review package. At C&EN, we are constantly caught up in deadlines, bringing you the most up-to-date news happening in the world of chemistry. The Year in Review package is our opportunity to look back and reflect on the stories we covered over the previous 12 months. This allows us to spot trends and generate ideas for the following year, as well as to celebrate the most important and impactful advances and developments of the year. We kick off our Year in Review in this week’s cover story by examining what 2016 held for the pharmaceuticals field. On page 38, for example, we look back at the Zika outbreak and how drugmakers’ efforts to combat the outbreak have yielded diagnostics and the first vaccine trials. On page 43, we remember the merger that never was: the Pfizer and Allergan megadeal, which was supposed to bring together the makers of Viagra and Botox in a $160 billion merger. For more on pharma giants you can check out the list of the top 10 drug firms of 2016 on page 48. And if that’s not enough,
F
ACS 2015 IRS Form 990 available The American Chemical Society’s 2015 IRS Form 990 is now available on ACS’s website. To access the information, go to www.acs.org and follow these instructions: Click on “About ACS,” and then click on “Financial,” which brings you to the “ACS Financial Information” page. Under the heading “ACS IRS Form 990,” click on “2015 IRS Form 990.” Also see the related “Guide to Schedule J” for explanatory information regarding ACS executive compensation. If you have access problems, contact
[email protected]. turn to page 37 to read about drug pricing and the controversial Epipen story that has recently been grabbing headlines. In the U.S., the year ends in a climate of uncertainty after Donald Trump’s election as President. What outcome that will have for the pharmaceutical enterprise or funding agencies is still unknown, so we can only wait and see. For our analysis, check page 40. And a final note: Next week, there won’t be an issue of C&EN, but continue to watch our website for daily updates. We’ll be releasing fresh Year in Review content throughout the month at yearinreview.cenmag.org. Look out for stories on CRISPR, TSCA reform, Brexit, and the Flint water crisis as well as our picks for the year’s top research papers, and much more. Or catch up with all our Year in Review analysis in our special Dec. 12/19 double issue. Happy December!
Editor-in-chief @BibianaCampos
Views expressed on this page are those of the author and not necessarily those of ACS.
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C&EN | CEN.ACS.ORG | DECEMBER 5, 2016