Bridging the performance gap from analytical to preparative - C&EN

Eng. News , 2005, 83 (23), Outside Back Cover. DOI: 10.1021/cen-v083n023.obc. Publication Date: June 06, 2005. Copyright © 2005 American Chemical ...
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Bridging the performance gap from analytical to preparative Efficient Target Isolation from Complex Crudes

Accurate Scale-up on SunFire™ columns in 0.1% TFA

Today's drug discovery environment demands the rapid isolation of high purity compounds with minimal chromatographic development.

Compounds: 1 . 8-Bromoguanosine 2. Acetanilide 3. Hydrocortisone 4. 6a-Methyl-1 7a-hydroxyprogesterone

Waters Optimum Bed Density (OBD™) preparative columns have been engineered to deliver consistent column-to-column performance, unmatched column lifetime with DMSO sample diluents, maximum loadability in simple mobile phase conditions, accurate scalability and high peak capacity.

5. 6. 7.

3-Aminofluoranthene 2-Bromofluorene Perylene 4.6 x 100 mm, 5 urn Injection Volume: 6 0 uL DMSO Total Load: 6.9 mg

19 x 100 mm, 5 urn Injection Volume: 1020 uL DMSO Total Mass Load:

Waters OBD™ columns are available in all of Waters innovative chemistries designed to meet every synthesis challenge.

115.7mg

For more information visit www.waters.com/bridgethegap and register for your free prep scale-up calculator.

For Purification v Confidence

Waters Corporation U.S.A. 508 478 2000/800 252 4752

* Note: the differences in peak scabs are due to the saturation response of PDA detector. Gradient Conditions: 5 to 95% CH..CN over 10 minutes.

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Atlantis Columns

SunFins" COLUMNS

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