Focus ing international competition will fine-tune their manufacturing pro cesses with analytical instrumentbased monitoring of critical com pounds," says the report. In the vanguard of developments in this area has been the Center for Pro cess Analytical Chemistry (CPAC), a cooperative academic-industrial en terprise founded by Bruce Kowalski, James Callis, and their colleagues at the University of Washington (Anal. Chem. 1984,56[1], 36 A). These re searchers recognized a trend that has already seen integrated-circuit manu facturers instituting on-line chromato graphic sampling systems to detect chip impurities and biotechnology companies installing analytical sen sors and spectrometers to monitor in put and product concentrations in fer mentation vats. Of course, recognition of the tre mendous potential of process analyti cal chemistry predates the establish ment of CPAC by many years. For ex ample, Sidney Siggia (then of Olin Mathieson, later to join the faculty at the University of Massachusetts) ex plained back in 1964 that "the signal from the analytical device can be used to activate computing and/or control
ling mechanisms so that the chemical process can be automatically kept within the desired limits In the application of analytical approaches for in-line process analysis, we have seen great advances. Almost any ana lytical tool is now available in an onstream form; i.e., infrared and ultravi olet, mass spectrometry, gas chroma tography, titration, colorimeters,... and many others" {J. Chem. Ed. 1964, 41, 329-30). However, process analyti cal chemistry has become considerably more important over the past few years as companies have had to pro duce more efficiently to compete in global markets, comply with increas ingly complex government regulations, and deal with burgeoning financial ex posures from high-award liability suits. Biotechnology is a third major area of potential growth for the analytical instrument industry, a fact exempli fied by recent events such as the ac quisition of Brownlee Labs by Applied Biosystems Inc. and the establishment of joint ventures such as Perkin-Elmer Cetus Instruments and HP Genenchem. The significance of the biotech nology-analytical chemistry interface has been frequently noted in ANAL-
LOW TEMPERATURE FREEZERS THAT ASSURE PERFORMANCE WHEN THE HEAT IS ON.
^enie 'TRvmr
Whether it's sample or specimen storage, or applications process ing, Puffer-Hubbard offers a no-nonsense alternative to your freezer shopping. Our freezers assure -90°C in work environments of up to +90°F. Puffer-Hubbard cools your budget too with prices that buy good reliable performance — and nothing less!
U
Write or call for more information on Puffer-Hubbard Laboratory Appliances, a name you can trust.
(see, for exam ple, Warren, Doris C. 1984,56[U], 1528-44 A; 1984,56[14], 1548-54 A; and Glajch, Joseph L. 1986,58[3], 385-94 A. The Hambrecht & Quist study is the latest instance of what seems to be a growing interest among investment analysts in the analytical instrument industry. (Companies such as Alex. Brown & Sons of Baltimore, Md., and L. F. Rothschild, Unterberg, Towbin of New York City have also followed the industry closely for the past few years.) This increased visibility has been helped along by the evident suc cess of recent start-ups such as Mattson Instruments, Zymark Corporation, and Nelson Analytical, by the advent of the first newsletter ("Analytical In strument Industry Report") to cover the industry in a comprehensive fash ion, and by investment seminars spon sored by organizations such as the Sci entific Apparatus Makers Association. It is hoped that this increased atten tion to the industry by the investment community will attract more resources to analytical instrumentation develop ment and, thus, ultimately redound to the benefit of the analytical chemistry community. S.A.B. YTICAL CHEMISTRY
* ' 11 flf Λ
,I H
One of chew tartHtaMliai »o*aa*v dous chemical. m M f f i m t « r « M Ç choosing the rif^|«CMt'tecoÂi*»'4' dangerous gBe&gMjm, Out «Mr
•\H -
cauku taunt 350 Park Ave., 11th floor New York, N.Y. 10022-6022
amWfltfKti
chômai labels. jnttNtt* * * M M " labelling syiKRU tbatweet die («Ht '^ight-to-Know" requirements.
f LAB SAFETY
1-800-521-8004
CIRCLE 168 ON READER SERVICE CARD 1088 A · ANALYTICAL CHEMISTRY, VOL. 58, NO. 11, SEPTEMBER 1986
CIRCLE 125 ON READER SERVICE CARD
