CORNING LABORATORY PRODUCTS - Analytical ... - ACS Publications

May 23, 2012 - CORNING LABORATORY PRODUCTS. Anal. Chem. , 1969, 41 (3), pp 26A–26A. DOI: 10.1021/ac60272a723. Publication Date: March 1969...
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1 DON'T LIKE TO ADMIT IT, BUT I MISSED PlPET CLASS IN SCHOOL

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26A · ANALYTICAL CHEMISTRY

Report weaker t h a n t h a t noted with croton oil and its purification products. When we move to the area of air pollution, we observe a family of compounds containing both initiators and promoters, such as phenols of unknown constitution, the question of their direct role remains open (31). There is however, no question that the cigarette smokers or urban populations exposed to automobile exhaust products have a significantly higher rate of lung cancer, but the correlation of all the different kind of exposures in relation to production of cancer remains extremely difficult. T h e situation is clearer when we have a starting point, for example, with uranium miners or chromium workers where the product of the radioactive metal radon, or the chromium metal are the obvious prime suspects (32). However, all the other known agents which increase lung cancer in the rest of the population serve to confuse the picture. For example, the smoking miner has twenty times the incidence of lung cancer t h a n his nonsmoking coworker (32). The air we breathe, contaminated with cigarette smoke or not, is clearly not the only source of carcinogens ; the food we eat and the drugs we take m a y make a sizable contribution. Prominent among the materials under suspicion are the aflatoxins, which appear to be the active carcinogens present in certain batches of peanut meal fed to a variety of domestic animals (33, 34). The chemical appears to arise from a fungus growing on the nut and is, perhaps, the most studied of the larger group of plant carcinogens which includes the cycasins, extracts of braken fern and extracts from a variety of fungi (3537). Aflotoxin Blt a liver carcinogen in rat, combines with D N A , reducing its priming activity with R N A polymerase; it fits well into the category of initiating chemicals described above. T h e cycasins are naturally occurring nitroso amines and appear to be metabolized to a proximal carcinogen methylazoxymethanol. Thus, the properties of these naturally occurring carcinogens are similar to those introduced by man.