new products
INSTRUMENTATION GC detector D-3-i-HP pulsed discharge helium ionization detector, which is designed for use with GC systems and fieldportable devices, is compatible with both capillary and packed columns. The nonradioactive, nondestructive detector has subpicogram sensitivity and close-to-true-mass response, which is linear over a wide range. If the helium discharge gas is doped with a suitable noble gas, the instrument acts as a photoionization detector for aliphatics, aromatics, amines, and other species. VICI • 401
tem designed for individual users and small groups involved in biomedical and materials research. The LSM 5 module can be fitted on the motorized versions of Zeiss upright and inverted microscopes. Images of 2048 x 2048 pixels digitized in 4096 gray levels can be obtained. One or two confocal channels and an optional transmitted light channel are available. The system can be used in fields such as cell biology, neurobiology, molecular biology, genetics, biochemistry, and immunology. Zeiss • 404
COLUMNS Peptides
Capillary electrochromatography TriSep is a dedicated CEC system capable of performing micro HPLC and CE analyses. Both gradient and isocratic models feature a UV detector with a standard capillary cell for on-column detection; HPLC pump(s) with a flow rate range of 1 µL–10 mL/min; highvoltage power supply; 10- or 20-nL injection valve with a 100-µL syringe and fill-port; chromatography data system; micro fluid-control elements; and two CEC columns. Unimicro Technologies • 402
Confocal laser microscope LSM 5 PASCAL confocal laser scanning microscope is a small compact sys-
Source 5RPC ST 4.6/150 is a prepacked stainless steel column designed for analytical and preparative reversedphase chromatography of peptides, protein fragments, and oligonucleotides. The medium is based on a 5-µm, monosized, rigid polystyrene/divinylbenzene matrix, which is stable over a pH range of 1–12. Amersham Pharmacia Biotech • 405
LITERATURE Syringes Brochure highlights syringes designed for LC and GC. The 9000, 5000, and 4000 series feature Teflon plungers, TPX flanges, and scale blades, respectively. General-purpose, standard plunger syringes are also described. Unimetrics • 407
Herbicides Application note 20 describes the analysis of phenylurea herbicides in river water using on-line solid-phase extraction. Sample preparation is performed on C8, 10 x 2-mm, 40-µm cartridges; the analytical analysis is run on a C18, 200 x 3-mm, 5-µm HPLC column. Jones Chromatography • 408
LC/MS/MS of nonsteroids Application note entitled “LC/PDAMS/MS Quantitative Analysis of NonSteroidal Anti-Inflammatory Drugs of Abuse in Horses” details how a photodiode array (PDA) and MS/MS provide structural information to confirm a compound’s identity in a single LC/MS/MS run. ThermoQuest• 409
Pharmaceuticals SelectaPore HPLC columns provide three distinct selectivities using two different C18 chemistries and two different silica pore sizes. Monomeric C18, 90-Å pore; monomeric C18, 300-Å pore; and polymeric C18, 300-Å pore columns are available. Vydac • 406
Fat in meat Application note 334 describes an accelerated solvent extraction method for determining the fat content in fresh and processed low- and high-fat meat products. The method can process up to 24 samples at 12 min each using only 20 mL of solvent. Dionex • 410
PCBs in fish UV–vis spectrophotometer Ultrospec 3000 scanning UV–vis spectrophotometer is intended for use in industrial and academic biopharmaceutical research laboratories. The bandwidth is < 1.8 nm. Results can be printed locally or downloaded to a spreadsheet. Built-in software applications include scanning, kinetics, standard curve, substrate concentration, and multiwavelength equation entry. It can store 50 methods and includes routines for quantitating nucleic acids, characterizing oligonucleotides, and determining proteins. Amersham Pharmacia Biotech • 403
Application note 337 describes an accelerated solvent extraction method for determining PCB content in fish tissue. The method can process a single sample in 20 min using only 40 mL of solvent. Dionex • 411
Taxol in serum Application note describes measuring taxol in serum using on-line solidphase extraction. Sample preparation is performed on a C18 column with 7-µm particles. Jones Chromatography • 412
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